AI Article Synopsis
- The study demonstrated a new method that combines ruthenium-catalyzed isomerization of allylic alcohols with enantioselective enzymatic reduction in a single aqueous process.
- The process achieved high conversion rates and enantioselectivities, efficiently using available catalysts without the need for additional coenzymes.
- Through optimization, the researchers created a cascade reaction where both the metal catalyst and biocatalyst worked together from the start.
Article Abstract
The ruthenium-catalyzed redox isomerization of allylic alcohols was successfully coupled with the enantioselective enzymatic ketone reduction (mediated by KREDs) in a concurrent process in aqueous medium. The overall transformation, formally the asymmetric reduction of allylic alcohols, took place with excellent conversions and enantioselectivities, under mild reaction conditions, employing commercially and readily available catalytic systems, and without external coenzymes or cofactors. Optimization resulted in a multistep approach and a genuine cascade reaction where the metal catalyst and biocatalyst coexist from the beginning.
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| http://dx.doi.org/10.1002/anie.201601840 | DOI Listing |
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