A nickel/N-heterocyclic carbene catalytic system has been established for decarbonylative borylation of amides with B2 nep2 by C-N bond activation. This transformation shows good functional-group compatibility and can serve as a powerful synthetic tool for late-stage borylation of amide groups in complex compounds. More importantly, as a key intermediate, the structure of an acyl nickel complex was first confirmed by X-ray analysis. Furthermore, the decarbonylative process was also observed. These findings confirm the key mechanistic features of the acyl C-N bond activation process.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/anie.201603068 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Nucleophilic addition of bulk chemicals with imines using N-functionalized hydroxylamine reagents as precursors.
Nat Commun
January 2025
College of Chemistry, Central China Normal University (CCNU), Wuhan, Hubei, PR China.
C-C and C-X bond forming reactions are essential tools in organic synthesis, constantly revolutionizing human life. Among the key methods for constructing new chemical bonds are nucleophilic addition reactions involving imines. However, the inherent challenges in synthesizing and storing imines have stimulated interest in designing stable precursors, which generates imines in situ during the reaction.
View Article and Find Full Text PDFResponse surface methodology and Box-Behnken design optimization of Sulfaquinoxaline removal efficiency and degradation mechanisms by Bacillus sp. strain DLY-11.
J Hazard Mater
December 2024
South China Institute of Environmental Sciences, MEE, Guangzhou, Guangdong 510655, China; State Environmental Protection Key Laboratory of Water Environmental Simulation and Pollution Control, Guangzhou, Guangdong 510655, China. Electronic address:
Antibiotic pollution, particularly the persistence of Sulfaquinoxaline (SQ) residues in livestock and poultry farming environments, has emerged as a pressing environmental concern. Despite this, there remains a limited understanding of the optimized conditions and mechanisms for the efficient degradation of SQ by microorganisms. To address this knowledge gap, we isolated Bacillus sp.
View Article and Find Full Text PDFDeciphering the N-substituent effects on biodegradation of sulfonamides: Novel insights revealed from molecular biology and computational chemistry approaches.
Water Res
December 2024
Institute of Environment and Ecology, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China. Electronic address:
Elucidating biodegradation mechanisms and predicting pollutant reactivities are essential for advancing the application of biodegradation engineering to address the challenge of thousands of emerging contaminants. Molecular biology and computational chemistry are powerful tools for this purpose, enabling the investigation of biochemical reactions at both the gene and atomic levels. This study employs the biodegradation of ten sulfonamide antibiotics as a case study to demonstrate the integration of genomics and quantum chemistry approaches in exploring the biodegradation behavior of emerging contaminants.
View Article and Find Full Text PDFTransforming an azaarene into the spine of fusedbicyclics via cycloaddition-induced scaffold hopping of 5-Hydroxypyrazoles.
Nat Commun
December 2024
National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, P.R. China.
Skeleton editing for heteroarenes, especially pyrazoles, is challenging and remains scarce because these non-strained aromatics exhibit inert reactivities, making them relatively inactive for performing a dearomatization/cleavage sequence. Here, we disclose a cycloaddition-induced scaffold hopping of 5-hydroxypyrazoles to access the pyrazolopyridopyridazin-6-one skeleton through a single-operation protocol. By converting a five-membered aza-arene into a five-unit spine of a 6/6 fused-bicyclic, this work unlocks a ring-opening reactivity of the pyrazole core that involves a formal C = N bond cleavage while retaining the highly reactive N-N bond in the resulting product.
View Article and Find Full Text PDFTorsional Structural Relaxation Caused by Pt-Pt Bond Formation in the Photoexcited Dimer of Pt(II) N ̂ C ̂ N Complex in Solution.
J Phys Chem Lett
December 2024
Molecular Spectroscopy Laboratory, RIKEN, 2-1 Hirosawa Wako, Saitama 351-0198, Japan.
[Pt(NCN)MeCN] (NCN = 1,3-di(2-pyridyl)benzene, MeCN = acetonitrile) forms oligomers in the ground state due to metallophilic interactions, and a Pt-Pt bond is formed with photoexcitation. Ultrafast excited-state dynamics of the [Pt(NCN)MeCN] dimer in acetonitrile is investigated by femtosecond time-resolved absorption (TA) and picosecond emission spectroscopy. The femtosecond TA signals exhibit 60 cm oscillations arising from the Pt-Pt stretching motion in the S dimer.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!