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Clinical Research Network: JHCRN Infrastructure and Lessons Learned.
Clin Transl Sci
January 2025
Johns Hopkins Clinical Research Network, Baltimore, Maryland, USA.
Clinical research studies are becoming increasingly complex resulting in compounded work burden and longer study cycle times, each fueling runaway costs. The impact of protocol complexity often results in inadequate recruitment and insufficient sample sizes, which challenges validity and generalizability. Understanding the need to provide an alternative model to engage researchers and sponsors and bringing clinical research opportunities to the broader community, clinical research networks (CRN) have been proposed and initiated in the United States and other parts of the world.
View Article and Find Full Text PDFHealthcare worker views on antimicrobial resistance in chronic respiratory disease.
Antimicrob Resist Infect Control
January 2025
Royal Brompton Hospital, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
Background And Objective: Antimicrobial resistance (AMR) is a global crisis, however, relatively little is known regarding its impact in chronic respiratory disease and the specific challenges faced by healthcare workers across the world in this field. We aimed to assess global healthcare worker views on the challenges they face regarding AMR in chronic respiratory disease.
Methods: An online survey was sent to healthcare workers globally working in chronic respiratory disease through a European Respiratory Society clinical research collaboration (AMR-Lung) focussed on AMR in chronic lung disease.
Timely access to specialist outpatient care: can applying systems thinking unblock our waiting lists?
BMC Health Serv Res
January 2025
Centre for the Business and Economics of Health (CBEH), The University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia.
Background: The purpose of this qualitative study was to focus on review and repeat review outpatients and the structural role they play in exacerbating waitlists for Specialist Outpatient (SOP) services in Queensland. Waitlists, which record the number of patients waiting for an initial consultation (new appointment), are an indicator of a health system under strain. Waiting too long to access SOP can have a detrimental effect on people's health outcomes.
View Article and Find Full Text PDFRelationship between platelet distribution width and non-dipping pattern in children with essential hypertension.
BMC Pediatr
January 2025
Department of Cardiology, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.
Background: Hypertension has shown a trend of prevalence at younger ages, and the non-dipping pattern is associated with target organ damage in hypertension. However, few studies have yet investigated the clinical characteristics and risk factors of non-dipper status in essential hypertension children. This study aimed to explore the clinical characteristics and possible indicators associated with non-dipper status in children with essential hypertension.
View Article and Find Full Text PDFPrescribing rate, healthcare utilization, and expenditure of older adults using potentially inappropriate medications in China: A nationwide cross-sectional study.
Chin Med J (Engl)
January 2025
Department of Pharmacy, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Key Laboratory of Assessment of Clinical Drugs Risk and Individual Application (Beijing Hospital), Beijing 100730, China.
Background: The use of potentially inappropriate medications (PIMs) is a major concern for medication safety as it may entail more harm than potential benefits for older adults. This study aimed to explore the prescribing rate, healthcare utilization, and expenditure of older adults using PIMs in China.
Methods: A cross-sectional analysis was conducted using a national representative database of all medical insurance beneficiaries across China, extracting ambulatory visit records of adults aged 65 years and above between 2015 and 2017.
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