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Comparative effects of finasteride and minoxidil on the male reproductive organs: A systematic review of in vitro and in vivo evidence.
Toxicol Appl Pharmacol
November 2023
Department of Animal Biology, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil; Department of General Biology, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.
Finasteride and minoxidil are medicaments commonly prescribed for treating benign prostatic hyperplasia (BPA), hypertension, and/or androgenetic alopecia (AGA). The mechanism of action of finasteride is based on the interference in androgenic pathways, which may lead to fertility-related disorders in men. Minoxidil, however, can act in multiple ways, and there is no consensus that its use can adversely affect male fertility.
View Article and Find Full Text PDFSuccessful treatment of hereditary hypotrichosis simplex by platelet rich plasma injection with topical minoxidil 2.
J Dermatolog Treat
December 2023
Dermatology and Venereology, Faculty of Medicine, Tanta University, Tanta, Egypt.
Article Synopsis
- Hereditary hypotrichosis simplex is a rare genetic condition that results in insufficient hair growth on the scalp, leading to issues with hair length and density.
- Diagnosis primarily involves ruling out other similar skin and hair disorders.
- A case study showed significant improvement in a 14-year-old patient after treatment with platelet rich plasma injections and topical minoxidil 2%, suggesting potential new treatment options for others with the condition.
Comprehensive review of oral minoxidil in alopecia.
J Cosmet Dermatol
November 2022
Department of Dermatology, Venereology and Leprology, All India Institute of Medical Sciences, Rajkot, India.
Article Synopsis
- This article explores the effectiveness of oral minoxidil as a treatment for various types of alopecia, highlighting its journey from topical formulations to systemic use.
- The research involved a thorough review of existing literature, including clinical trials and case reports, to assess the role of oral minoxidil in treating different alopecia conditions.
- The findings indicate that oral minoxidil shows promising results with fewer side effects, particularly for androgenetic alopecia and female pattern hair loss, presenting a viable alternative to topical treatments that often suffer from compliance issues.
Exploring the effects of Chinese herbal ingredients on the signaling pathway of alopecia and the screening of effective Chinese herbal compounds.
J Ethnopharmacol
August 2022
Institute of Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, China. Electronic address:
Ethnopharmacological Relevance: alopecia is a hair disorder that can add a significant medical and psychological burden to patients. Currently, the FDA-approved drugs for the treatment of androgenetic alopecia (AGA) are minoxidil and finasteride and immunosuppressives are therapeutic options for alopecia areata (AA), but the objective adverse effects and high cost of these treatments reduce patient compliance and thus the effectiveness of the drugs. Traditional Chinese medicine (TCM) has good efficacy, a high safety profile and low treatment costs, but its mechanism of action is still not fully understood.
View Article and Find Full Text PDFClinicopathologic Characteristics and Response to Treatment of Persistent Chemotherapy-Induced Alopecia in Breast Cancer Survivors.
JAMA Dermatol
November 2021
The Dermatology Centre, Salford Royal National Health Service Foundation Trust, Salford, Greater Manchester, United Kingdom.
Importance: Alopecia induced by classic chemotherapy affects up to 65% of patients and is usually reversible. However, there are increasing reports of persistent chemotherapy-induced alopecia (pCIA), especially for patients treated with taxane-containing chemotherapy regimens.
Objective: To analyze the clinicopathologic characteristics and response to treatment of patients with pCIA after chemotherapy for breast cancer.
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