Omega (n-)3 and n-6 long chain polyunsaturated fatty acids (LCPUFA) accumulation in the infant brain after birth is strongly driven by dietary supply of n-3 and n-6 LCPUFAs and their C18 precursors through breast milk or infant formula. n-3 LCPUFA accretion is associated with positive effects on neurodevelopmental outcome whereas high n-6 LCPUFA accumulation is considered disadvantageous. Maternal diet is crucial for breast milk fatty acid composition. Unfortunately, global increases in linoleic acid (C18:2n-6; LA) intake have dramatically increased n-6 LCPUFA and reduced n-3 LCPUFA availability for breastfed infants. We investigated the effects of reducing maternal dietary LA, or increasing n-3 LCPUFA, during lactation on milk and offspring brain fatty acids in mice. Offspring brain n-3 LCPUFA was higher following both interventions, although effects were mediated by different mechanisms. Because of competitive interactions between n-3 and n-6 fatty acids, lowering maternal LA intake may support neurodevelopment in breastfed infants.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.plefa.2016.05.001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Modulatory effect of Echium plantagineum oil on the n-3 LC-PUFA biosynthetic capacity of chicken (Gallus gallus).
Poult Sci
January 2025
Departamento de Biología Animal, Edafología y Geología, Universidad de La Laguna. Avenida Astrofísico Francisco Sánchez s/n, 38206 La Laguna, Tenerife, Spain.
Poultry can be a sustainable source of eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3) through the bioconversion of dietary alpha-linolenic acid (ALA, 18:3n-3). However, this process is currently limited by the high n-6/n-3 ratio in poultry diets affecting the competition between n-6 and n-3 fatty acids (FA) for the same biosynthetic enzymes, and the rate-limiting Δ6 desaturase which act at both, the first and final steps of DHA synthesis pathway. Echium plantagineum oil (EO) is an unusual source of stearidonic acid (SDA, 18:4n-3) which bypasses the first Δ6 desaturase step potentially increasing n-3 long-chain polyunsaturated fatty acids (LC-PUFA) synthesis.
View Article and Find Full Text PDFMaternal Omega-6/Omega-3 Concentration Ratio During Pregnancy and Infant Neurodevelopment: The ECLIPSES Study.
Nutrients
January 2025
Nutrition and Mental Health (NUTRISAM) Research Group, Universitat Rovira i Virgili, 43201 Reus, Spain.
Background: The balance of omega-6/omega-3 (-6/-3) is crucial for proper brain function as they have opposite physiological roles.
Objectives: To analyze the association between maternal serum ratios of -6/-3 in the first and third trimesters of pregnancy and the neurodevelopment of their children in the early days after birth in the population of Northern Spain's Mediterranean region.
Methods: Longitudinal study in which 336 mother-child pairs participated.
Maternal Long-Chain Polyunsaturated Fatty Acids Status in Pregnancy and Newborn Body Composition.
Nutrients
December 2024
Department of Functional and Organic Food, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences, Nowoursynowska 159c, 02-776 Warsaw, Poland.
Background: A number of clinical studies have shown a positive association between the maternal -3 PUFA status during pregnancy and fetal and newborn development and health. Despite this well-documented role of -3 PUFAs in pregnancy, data on maternal the LC-PUFAs status during pregnancy in the Indonesian population, to our knowledge, are not yet available. This study reports on the LC-PUFA dietary intake among pregnant women in a suburban population of Bogor City, West Java, Indonesia.
View Article and Find Full Text PDFDeterminants of maternal and infant omega-3 status at 3 months postpartum: findings from the APrON longitudinal cohort study.
Am J Clin Nutr
January 2025
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada. Electronic address:
Background: Omega-3 long-chain-polyunsaturated fatty acids (LCPUFAs) are important dietary components for maternal and infant health during pregnancy and lactation.
Objectives: This study investigated determinants of maternal and infant LCPUFAs status at 3 mo postpartum and the relationship between maternal serum, maternal milk, and infant LCPUFAs.
Methods: This cross-sectional study included mothers (n = 1481) and their offspring (n = 526) at 3 mo postpartum from the Alberta Pregnancy Outcomes and Nutrition (APrON) cohort.
Comparative Analysis of Fatty Acid Bioaccessibility in Commercial Marine Oil Supplements: An In Vitro Integrated Analytical Study.
Foods
December 2024
Department of Agricultural and Food Sciences (DISTAL), University of Bologna, 47521 Cesena, Italy.
Zooplankton such as copepods and krill are currently used to produce marine oil supplements, with the aim of helping consumers achieve the recommended intake of n-3 long chain polyunsaturated fatty acids (n-3 LC-PUFAs). Oils from lower trophic levels differ from fish oil in the distribution of lipids into different classes, and this can influence the bioaccessibility of fatty acids, i.e.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!