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Polyphenol Containing Sorghum Brans Exhibit an Anti-Cancer Effect in Apc Min/+ Mice Treated with Dextran Sodium Sulfate.
Int J Mol Sci
August 2021
Grain Quality and Structure Research Unit, Agricultural Research Service, U.S. Department of Agriculture, Manhattan, KS 66502, USA.
Colon cancer (CC) is considered a high-risk cancer in developed countries. Its etiology is correlated with a high consumption of red meat and low consumption of plant-based foods, including whole grains. Sorghum bran is rich in polyphenols.
View Article and Find Full Text PDFAntimicrobial Activity of Sorghum Phenolic Extract on Bovine Foodborne and Mastitis-Causing Pathogens.
Antibiotics (Basel)
May 2021
Department of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS 66506, USA.
Antimicrobial resistance in bacterial pathogens associated with bovine mastitis and human foodborne illnesses from contaminated food and water have an impact on animal and human health. Phenolic compounds have antimicrobial properties and some specialty sorghum grains are high in phenolic compounds, and the grain extract may have the potential as a natural antimicrobial alternative. The study's objective was to determine antimicrobial effects of sorghum phenolic extract on bacterial pathogens that cause bovine mastitis and human foodborne illnesses.
View Article and Find Full Text PDFSorghum Phenolic Compounds Are Associated with Cell Growth Inhibition through Cell Cycle Arrest and Apoptosis in Human Hepatocarcinoma and Colorectal Adenocarcinoma Cells.
Foods
May 2021
Department of Food Nutrition Dietetics and Health, Kansas State University, Manhattan, KS 66506, USA.
Phenolic compounds in some specialty sorghums have been associated with cancer prevention. However, direct evidence and the underlying mechanisms for this are mostly unknown. In this study, phenolics were extracted from 13 selected sorghum accessions with black pericarp while F10000 hybrid with white pericarp was used as a control, and cell growth inhibition was studied in hepatocarcinoma HepG2 and colorectal adenocarcinoma Caco-2 cells.
View Article and Find Full Text PDFAnticancer Activity of a Novel High Phenolic Sorghum Bran in Human Colon Cancer Cells.
Oxid Med Cell Longev
May 2021
Agricultural Research Service, U.S. Department of Agriculture, Center for Grain and Animal Health Research, Manhattan, KS 66502, USA.
Human colon cancer is the third leading cause of mortality in the United States and worldwide. Chemoprevention using diet is widely accepted as a promising approach for cancer management. Numerous population studies indicate a negative correlation between the incidence of colon cancer and consumption of whole grains with a high content of bioactive phenolic compounds.
View Article and Find Full Text PDFAdvancing provitamin A biofortification in sorghum: Genome-wide association studies of grain carotenoids in global germplasm.
Plant Genome
March 2020
Department of Agronomy, Kansas State University, Manhattan, KS, 66506, USA.
Vitamin A deficiency is one of the most prevalent nutritional deficiencies worldwide. Sorghum [Sorghum bicolor L. (Moench)] is a major cereal crop consumed by millions of people in regions with high vitamin A deficiency.
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