AI Article Synopsis
- The study explored the link between chronic pancreatitis and factors like smoking and genetic mutations among different groups of people.
- Results indicated that a significant majority (91.4%) of patients with alcoholic pancreatitis were smokers, compared to 73.3% of those without pancreatic disease.
- The N34S mutation of the SPINK1 gene was more common in chronic pancreatitis patients, suggesting a correlation between this mutation and the disease, while other mutations had less clear associations.
Article Abstract
Objective: This study aimed to investigate the association between chronic pancreatitis and smoking or genetic mutations.
Methods: The study sample comprised 148 patients with chronic pancreatitis, 110 chronic alcoholic subjects without pancreatic disease, and 297 volunteer blood donors.
Results: Of the patients with chronic pancreatitis, 74% had alcoholic etiology and 26% had idiopathic pancreatitis. The frequency of smoking was 91.4% in patients with alcoholic pancreatitis, higher than 73.3% in alcoholic subjects without pancreatitis (P < 0.01). The difference in smoking frequency was not significant between the patients with idiopathic pancreatitis and blood donors. The N34S mutation of serine peptidase inhibitor, Kazal type 1 (SPINK1) was found in 2.7% of patients with chronic alcoholic pancreatitis, in 5.3% of patients with idiopathic pancreatitis, and in 0.4% of blood donors (P = 0.02). The P55S mutation of SPINK1 was found in 2.7% of patients with alcoholic pancreatitis and in 0.7% of blood donors (P = 0.12). The R254W mutation of chymotrypsin C was found in 0.9% of patients with alcoholic pancreatitis, in 0.9% of chronic alcoholic subjects without pancreatitis, and in 0.4% of blood donors (P = 0.75). In all cases, the mutations were heterozygous.
Conclusions: Smoking and the N34S mutation of SPINK1 were positively correlated with chronic pancreatitis.
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| http://dx.doi.org/10.1097/MPA.0000000000000650 | DOI Listing |
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