AI Article Synopsis
- Primary hyperparathyroidism (PHPT) is an endocrine disease characterized by excessive secretion of parathyroid hormone (PTH), leading to elevated serum calcium levels and severe bone conditions like osteitis fibrosa cystica.
- The condition causes increased bone turnover, resulting in osteoclastomas or "brown tumors," which are benign bone lesions.
- A rare form of PHPT, known as hyperparathyroidism-jaw tumor (HPT-JT) syndrome, can have malignant parathyroid tumors and is associated with fibrous jaw tumors and nonendocrine cancers.
Article Abstract
Primary hyperparthyrodism (PHPT) is a common endocrine disease. It results from an inappropriate parathyroid hormone (PTH) secretion relative to serum ionized calcium level. Clinical manifestation of severe PHPT include bone disease called osteitis fibrosa cystica which reflects an increase osteoclastic resorption and osteoblastic activity. This high bone turnover is responsible of the occurrence of osteoclastomas, also named "brown tumors" (1). Rarely, PHPT may occur in inherited forms with association to fibrous jaw tumor that are unrelated to hyperparathyroidism. In this uncommon disease: hyperparathyroidism-jaw tumor (HPT-JT) syndrome, parathyroid tumor is frequently malignant and usually associated with nonendocrine malignancies (2). We report a case of a HPT-JT syndrome to focus on the differential diagnosis with brown tumors.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869961 | PMC |
| http://dx.doi.org/10.11138/ccmbm/2016.13.1.064 | DOI Listing |
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