This study evaluated the depth of cure (DOC) of packable and flowable bulk-fill resin-based composites (RBCs) including PRG (prereacted glass ionomer) and short-fiber materials. The materials were placed in a black split-mold with a 7 mm deep recess and cured at 700 mW/cm(2) for 20 s using a LED curing light. DOC was assessed using the ISO scraping and Knoops hardness tests. Data (n=5) were computed and analyzed using one-way ANOVA/Scheffe's post hoc test (p<0.05). ISO DOC ranged from 3.66 to 2.54 mm while DOC based on hardness testing ranged from 3 to 1.5 mm. For all materials, a decrease in hardness was observed with increasing depths. The DOC of bulk-fill RBCs was product dependent and greater than standard composites. At 4 mm depth, none of the bulk-fill RBCs had a depth: top hardness ratio of 0.8 and above.
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http://dx.doi.org/10.4012/dmj.2015-402 | DOI Listing |
Front Immunol
January 2025
Innovation & Research Department, OriCell Therapeutics Co. Ltd., Shanghai, China.
Systemic lupus erythematosus (SLE) and lupus nephritis (LN) are debilitating autoimmune disorders characterized by pathological autoantibodies production and immune dysfunction, causing chronic inflammation and multi-organ damage. Despite current treatments with antimalarial drugs, glucocorticoids, immunosuppressants, and monoclonal antibodies, a definitive cure remains elusive, highlighting an urgent need for novel therapeutic strategies. Recent studies indicate that chimeric antigen receptor T-cell (CAR-T) therapy has shown promising results in treating B-cell malignancies and may offer a significant breakthrough for non-malignant conditions like SLE.
View Article and Find Full Text PDFInt J Biol Sci
January 2025
Health Management Center, General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, China.
Exosomes are a member of extracellular vesicles. However, their biological characteristics differ from those of other vesicles, and recently, their powerful functions as information molecules, biomarkers, and carriers have been demonstrated. Malignancies are the leading cause of high morbidity and mortality worldwide.
View Article and Find Full Text PDFSci Rep
December 2024
Department of Clinical Biochemistry, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
This study explores the role of LINC00839 and its potential interaction with the miR-195-5p/cyclin E1 (CCNE1) axis in oral squamous cell carcinoma (OSCC). Using The Cancer Genome Atlas, we analyzed lncRNA, miRNA, and mRNA sequencing data for OSCC. Different online tools were applied to detect lncRNA-related miRNAs and their target mRNAs, forming a lncRNA/miRNA/mRNA axis.
View Article and Find Full Text PDFMalar J
December 2024
Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil.
Background: To eliminate malaria by 2035, Brazil must address Plasmodium vivax. Previously, first-line treatment was chloroquine plus 7-day primaquine (PQ) without glucose-6-phosphate dehydrogenase (G6PD) deficiency testing. In 2021, point-of-care quantitative G6PD testing and single-dose tafenoquine (TQ) were piloted in two municipalities.
View Article and Find Full Text PDFDent Mater
December 2024
Division of Dentistry, School of Medical Sciences, University of Manchester, Manchester, UK; Photon Science Institute, University of Manchester, Manchester, UK. Electronic address:
Objective: Zinc oxide (ZnO) powder possesses antibacterial activity and although white in color, it can severely reduce the depth of cure (DoC) of resin-based composite (RBC). This study investigated the effect of unary and binary photoinitiator systems on the DoC and degree of conversion (DC) of formulated RBC containing ZnO-nanoparticles.
Methods: Fourteen RBCs (n = 3/group) were formulated consisting of 50 wt% mixture of monomers (Bis-GMA, TEGDMA, and UDMA) and 50 wt% fillers (inert barium glass powder and silica nanoparticles).
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