Objectives: To investigate the prevalence of leishmaniasis in dogs in the UK and to describe clinical presentation, clinicopathological abnormalities, therapeutic protocols and outcome in this non-endemic country.
Materials And Methods: Medical records of dogs diagnosed with leishmaniasis at seven referral centres in the UK were retrospectively reviewed.
Results: The prevalence was between 0·007 and 0·04% with a higher number of cases in southern England. All dogs had a history of travel to or from an endemic country. Lethargy, dermatological disease, decreased appetite and lameness were the most common reasons for presentation. Allopurinol was used alone for treatment in the majority of cases.
Clinical Significance: Although rare, leishmaniasis should be considered in dogs in the UK if they have compatible clinical signs and history of travel to or from endemic areas.
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http://dx.doi.org/10.1111/jsap.12503 | DOI Listing |
Pathogens
December 2024
Institute of Microbiology, Department for Environment Constructions and Design, University of Applied Sciences and Arts of Southern Switzerland (SUPSI), 6850 Mendrisio, Switzerland.
Although Switzerland is currently not endemic for canine leishmaniosis (CanL), imported cases of this emerging zoonosis are regularly detected. Also, phlebotomine sand flies, vectors of the causative agent , are present in the southern part of the country, in Canton Ticino, and endemic foci of CanL have been recently described in neighboring Italian municipalities. In 2022 and 2023, we evaluated the distribution of phlebotomine sand flies and the presence of antibodies against in domestic dogs and cats in Ticino and Mesolcina (Canton of Grisons).
View Article and Find Full Text PDFVet Parasitol
January 2025
Department of Veterinary Clinic and Surgery, Veterinary School, Federal University of Minas Gerais - UFMG, Belo Horizonte, Minas Gerais, Brazil; National Institute of Science and Technology in NanoBiopharmaceutics (INCT-Nanobiofar), Belo Horizonte, Minas Gerais, Brazil.
Cardiovascular involvement in Leishmania sp. infections still requires further elucidation, with cutaneous and organic changes being more frequently observed. The aim of this study was to conduct a systematic review of cardiovascular involvement in dogs with canine visceral leishmaniasis, considering a publication span of over 80 years.
View Article and Find Full Text PDFPLoS Negl Trop Dis
December 2024
Genômica Funcional de Parasitos, Instituto René Rachou-Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais, Brazil.
Background: Visceral leishmaniasis (VL) is an infectious parasitic disease caused by the species Leishmania (Leishmania) infantum in the Mediterranean Basin, the Middle East, Central Asia, South America, and Central America, and Leishmania (Leishmania) donovani in Asia and Africa. VL represents the most severe and systemic form of the disease and is fatal if left untreated. Vaccines based on chimeric or multiepitope antigens hold significant potential to induce a highly effective and long-lasting immune response against infections by these parasites.
View Article and Find Full Text PDFParasit Vectors
December 2024
College of Public Health, University of Iowa, Iowa City, IA, USA.
Background: Visceral leishmaniosis (VL) is the most severe form of human leishmaniosis, with an estimated 95% case fatality if left untreated. Dogs act as peridomestic reservoir hosts for the protozoan parasite Leishmania infantum, a causative agent for human leishmaniosis, endemic throughout the Mediterranean basin. To assure consistent and accurate surveillance of canine infection and prevent transmission to people, consistent diagnosis of canine L.
View Article and Find Full Text PDFAnal Bioanal Chem
December 2024
Institute of Veterinary Medicine and Animal Sciences, Estonian University of Life Sciences, 51006, Tartu, Estonia.
The analysis of the volatile compounds released by biological samples represents a promising approach for the non-invasive diagnosis of a disease. The present study, focused on a population of dogs infected with canine leishmaniasis, aimed to decipher the volatolomic profile associated with this disease in dogs, which represent the main animal reservoir for Leishmania pathogen transmission to humans. The volatiles emitted by the breath and hair of dogs were analysed employing the gas chromatography-mass spectrometry (GC-MS) technique.
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