Aspirin vs Heparin for the Prevention of Preeclampsia.

Curr Hypertens Rep

First Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece.

Published: July 2016

AI Article Synopsis

  • Preeclampsia is a serious pregnancy-related condition characterized by high blood pressure, leading to maternal and fetal health risks, and delivering the baby is the only known resolution.
  • Various preventive treatments are being explored, mainly targeting early placental development, with low-dose aspirin showing promise, particularly when started before 16 weeks of pregnancy.
  • Heparin may also help in prevention, either alone or with aspirin, though its effectiveness remains uncertain based on conflicting study results.

Article Abstract

Preeclampsia is a hypertensive disorder of pregnancy that remains a significant cause of maternal morbidity and mortality worldwide. Preeclampsia can be resolved by delivery, and most of the proposed preventive treatment approaches are based on processes involved in placental development in early pregnancy. Yet, none of these has been established in clinical practice. Low-dose aspirin is the most promising candidate, nevertheless; while some individual randomized controlled trials showed minimal or no statistically significant benefit, recent metanalyses showed that early initiation before 16 weeks of gestation is associated with prevention of early-onset preeclampsia and reduction in prevalence of perinatal death or morbidity of pregnant women. Heparin could be an alternative antithrombotic and anti-inflammatory median to prevent preeclampsia either alone or in combination with aspirin; however, results are conflicting concerning efficacy.

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Source
http://dx.doi.org/10.1007/s11906-016-0664-3DOI Listing

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