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The role of microbiome in the development of gluten-related disorders.
Best Pract Res Clin Gastroenterol
September 2024
Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, USA. Electronic address:
Gluten-related disorders (GRD) include celiac disease (CD), non celiac gluten sensitivity (NCGS) and wheat allergy (WA), conditions that are associated with the ingestion of gluten-containing food. Gut microbiota composition and function may be involved in the pathogenesis of GRD. In untreated CD the microbiota is characterized by a reduction in beneficial microbes like Lactobacillus and Bifidobacterium and an increase in pathogenic ones such as Bacteroides and E.
View Article and Find Full Text PDFMultiwavelength photobiomodulation in atrophic age-related macular degeneration.
Eur J Ophthalmol
November 2024
School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
Purpose: To evaluate photobiomodulation (PBM) safety and efficacy in patient with atrophic AMD and to explore tissue effects using Spectrally Resolved Autofluorescence (SrAF) to identify a potential biomarker indicative of mitochondrial activity, the primary PBM target.
Methods: This retrospective, non-comparative case series involved six eyes of five patients with atrophic AMD, conducted at the Medical Retina and Imaging Unit, IRCCS San Raffaele Hospital in Milan, Italy. At baseline and follow-ups (after one and three months) a complete ophthalmological assessment and multimodal imaging, including spectrally resolved autofluorescence (SrAF), were performed.
Impact of postprogression therapies on overall survival: Recommendations from the 2023 kidney cancer association think tank meeting.
Urol Oncol
November 2024
Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA. Electronic address:
Modern advances in systemic and localized therapies for patients with renal cell carcinoma (RCC) have significantly improved patients' outcomes. If disease progression occurs after initial treatment, clinicians often have multiple options for a first salvage therapy. Because salvage and initial treatments both may affect overall survival time, and they may interact in unanticipated ways, there is a growing need to determine sequences of initial therapy and first salvage therapy that maximize overall survival while maintaining quality of life.
View Article and Find Full Text PDFMenopausal symptoms in breast cancer survivors on adjuvant endocrine therapy compared with those of menopausal women.
Maturitas
January 2025
IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 5, 16132 Genoa, Italy. Electronic address:
Objectives: To compare menopausal symptoms of breast cancer survivors on adjuvant endocrine therapy with those of menopausal women.
Study Design: In a retrospective nested case-control study menopausal symptoms were compared of breast cancer survivors in pre-, peri- or post-menopause at the time of diagnosis, on tamoxifen or an aromatase inhibitor, plus a gonadotrophin-releasing hormone analogue, if pre- or peri-menopausal, and age-matched control women either in the late peri-menopause, or in surgical or in physiological post-menopause on no hormone replacement therapy. Differences between women on tamoxifen and those on aromatase inhibitors were also evaluated.
Relaxivity and In Vivo Human Performance of Brand Name Versus Generic Ferumoxytol.
Invest Radiol
October 2024
From the Department of Radiology, University of Wisconsin-Madison, Madison, WI (R.A.V., D.T., J.R., S.B.R.); Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands (R.A.V.); Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI (L.M.); Department of Mechanical Engineering, University of Wisconsin-Madison, Madison, WI (J.R.); Department of Medical Physics, University of Wisconsin-Madison, Madison, WI (S.B.R.); Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI (S.B.R.); Department of Medicine, University of Wisconsin-Madison, Madison, WI (S.B.R.); and Department of Emergency Medicine, University of Wisconsin-Madison, Madison, WI (S.B.R.).
Objectives: Ferumoxytol is a superparamagnetic iron-oxide product that is increasingly used off-label for contrast-enhanced magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA). With the recent regulatory approval of generic ferumoxytol, there may be an opportunity to reduce cost, so long as generic ferumoxytol has similar imaging performance to brand name ferumoxytol. This study aims to compare the relaxation-concentration dependence and MRI performance of brand name ferumoxytol with generic ferumoxytol through phantom and in vivo experiments.
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