AI Article Synopsis
- Minocycline is identified as a broad-spectrum antibiotic often thought to inhibit microglia, which are immune cells in the brain.
- Many studies have attributed certain pharmacological effects of minocycline to this supposed inhibition, but the actual mechanisms at the molecular and cellular levels remain unclear.
- The article evaluates the evidence supporting minocycline as a true microglia inhibitor and suggests careful interpretation of research findings involving this drug.
Article Abstract
Minocycline, a second generation broad-spectrum antibiotic, has been frequently postulated to be a "microglia inhibitor." A considerable number of publications have used minocycline as a tool and concluded, after achieving a pharmacological effect, that the effect must be due to "inhibition" of microglia. It is, however, unclear how this "inhibition" is achieved at the molecular and cellular levels. Here, we weigh the evidence whether minocycline is indeed a bona fide microglia inhibitor and discuss how data generated with minocycline should be interpreted. GLIA 2016;64:1788-1794.
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| http://dx.doi.org/10.1002/glia.23007 | DOI Listing |
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