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http://dx.doi.org/10.1183/13993003.00435-2016 | DOI Listing |
Front Pharmacol
December 2024
Department of Respiratory Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Pulmonary diseases are a major category of diseases that pose a threat to human health. The most common drugs currently used to treat lung diseases are still chemical drugs, but this may lead to drug resistance and damage to healthy organs in the body. Therefore, developing new drugs is an urgent task.
View Article and Find Full Text PDFJ Respir Biol Transl Med
March 2025
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Chronic obstructive pulmonary disease (COPD) and lung cancer are closely linked, with individuals suffering from COPD at a significantly higher risk of developing lung cancer. The mechanisms driving this increased risk are multifaceted, involving genomic instability, immune dysregulation, and alterations in the lung environment. Neutrophils, the most abundant myeloid cells in human blood, have emerged as critical regulators of inflammation in both COPD and lung cancer.
View Article and Find Full Text PDFToxicol Res (Camb)
January 2025
Department of Respiratory and Critical Care Medicine, The People's Hospital of Mengzi, No. 89 Tianma Road, Mengzi, Yunnan Province 661100, China.
extract (GBE), a therapeutic drug, has anti-inflammatory and antioxidant effects that protect cells from harmful substances. Although GBE has been extensively studied in the prevention and treatment of lung diseases, its mechanism of action in chronic obstructive pulmonary disease (COPD) is unclear. In the present study, cigarette smoke extract (CSE) and cigarette smoke (CS) were used to induce COPD in cell and animal models.
View Article and Find Full Text PDFFront Bioeng Biotechnol
December 2024
Cancer Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Lung diseases account for over four million premature deaths every year, and experts predict that this number will increase in the future. The top cause of death globally is diseases which include conditions like lung cancer asthma and COPD. Treating severe acute lung injury is a complex task because lungs struggle to heal themselves in the presence of swelling inflammation and scarring caused by damage, to the lung tissues.
View Article and Find Full Text PDFZhonghua Jie He He Hu Xi Za Zhi
January 2025
National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Hetao Institute of Guangzhou National Laboratory, Shenzhen518000, China.
Chronic obstructive pulmonary disease (COPD) is a major global public health problem and the burden of disease is estimated to continue to increase. Since 2023, significant progress has been achieved in the early identification, pathogenesis, biomarkers, and personalized treatment of COPD. Early-stage COPD, as defined by varying criteria, has been shown to have distinct epidemiological features that affect disease prognosis, emphasizing the importance of early monitoring and intervention.
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