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Multifunctional NO supramolecular nanomedicine for thrombus risk reduction and intimal hyperplasia inhibition.
J Mater Chem B
January 2025
Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.
Cardiovascular diseases (CVDs) are the foremost cause of mortality worldwide, with incidence and mortality rates persistently climbing despite extensive research efforts. Innovative therapeutic approaches are still needed to extend patients' lives and preserve their health. In the present study, novel supramolecular nanomedicine with both nitric oxide (NO) and antioxidant releasing ability was developed to enhance therapeutic efficacy against vascular injuries.
View Article and Find Full Text PDFAssessment of ipsilateral and contralateral perfusion after contrast compression therapy of upper limb muscles in MMA athletes - a cross-over study.
Front Physiol
December 2024
Institute of Physiotherapy and Health Sciences, The Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland.
Objective: The primary aim of this study was to compare the immediate effect of contrast compression therapy with the use of Game Ready (GRT) on hyperaemic reactions in the upper limb on the application and contralateral sides, specifically in the context of mixed martial arts (MMA) athletes.
Design: In this experimental, single-blind, randomized crossover study, we recruited 30 male volunteers training in MMA (mean age: 28.33 ± 3.
The evolving understanding of systemic mechanisms in organ-specific IgA nephropathy: a focus on gut-kidney crosstalk.
Theranostics
January 2025
Renal Division, Peking University First Hospital, Beijing, China.
The interplay between multiple organs, known as inter-organ crosstalk, represents a complex and essential research domain in understanding the mechanisms and therapies for kidney diseases. The kidneys not only interact pathologically with many other organs but also communicate with other systems through various signaling pathways. It is of paramount importance to comprehend these mechanisms for the development of more efficient therapeutic strategies.
View Article and Find Full Text PDFGanglioside GA2-mediated caspase-11 activation drives macrophage pyroptosis aggravating intimal hyperplasia after arterial injury.
Int J Biol Sci
January 2025
Department of Cardiology, Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Intimal hyperplasia (IH) remains a significant clinical problem, causing vascular intervention failure. This study aimed to elucidate whether gangliosides GA2 accumulated in atherosclerotic mouse aortae and plasma promote the development of IH. We identified that GA2 was remarkably accumulated in both artery and plasma of atherosclerotic patients and mice.
View Article and Find Full Text PDFHealth-related quality of life profiles in patients with rheumatoid arthritis: a latent profile analysis.
Front Public Health
January 2025
Department of Gynecological Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Background: Rheumatoid arthritis (RA) is a common rheumatic disease that most commonly affects joints and negatively impacts individuals' health-related quality of life (HRQoL). Although some studies have explored HRQoL of RA patients, existing studies treated RA patients as a homogeneous group based on their overall HRQoL and ignore the heterogeneity of patients' HRQoL patterns. This study aimed to identify subgroups of RA patients based on their HRQoL and variables associated with group membership.
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