AI Article Synopsis
- DNA structures can be altered or damaged due to external (exogenous) or internal (endogenous) factors during cell division.
- If DNA damage is not repaired effectively, it can result in cell cycle arrest or programmed cell death (apoptosis).
- Exploiting the rapid growth of cancer cells, inducing DNA damage and promoting apoptosis are key strategies in cancer treatment, with various natural compounds showing promise in inhibiting cancer cell growth.
Article Abstract
The DNA structures could be altered or even damaged by exogeous or endogenous factors during cell proliferation. Failure of effective and timely repair will lead to cell cycle arrest or apoptosis. By taking the advantage of the quick proliferation of cancer cells, DNA damage induction, cell cycle arrest and apoptosis promotion have become important strategies for ant-cancer chemotherapy. Previous reports showed that an array of natural compounds inhibit cancer cell proliferation by inducing DNA damage, which have therapeutic potentials for anti-cancer drug research and development.
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