The anticonvulsant effect of a series of 6-alkyl-N,N-disubstituted-2-pyridinamines is described. An investigation was carried out to optimize the anticonvulsant activity and reduce behavioral side effects in this series. Three compounds (7, 8, 10; Table I) were selected from initial screening for a more complete pharmacological evaluation. While each of these compounds was a potent anticonvulsant agent with ED50 values from 5 to 10 mg/kg, the activity was accompanied by significant behavioral side effects including decreased spontaneous locomotion, ataxia, and ptosis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/jm00126a015 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Reduction Mammaplasty: Closed Suction Drains Do Not Reduce Hematoma or Seroma But Increase Infection Risk.
Ann Plast Surg
February 2025
From the Department of Plastic Surgery, Vanderbilt University Medical Center, Nashville, TN.
Background: While there is mounting evidence that closed suction drains are not necessary, there is a paucity of literature to demonstrate that drains are harmful after breast reduction. The purpose of this study was to investigate the effect of drains on postoperative seroma, hematoma, and infection, as well as elucidate any risk factors that may be implicated in the development of these complications.
Methods: A retrospective cohort study was conducted of all reduction mammaplasty procedures at our university medical center between 2010-2020.
Bottlebrush Pastes as a Platform for Solvent-Free, Injectable, and Shape-Persistent Materials with Tissue-Mimetic Viscoelasticity.
ACS Appl Mater Interfaces
January 2025
Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill 27599, United States.
Architecturally hindered crystallization of bottlebrush graft copolymers offers a reaction- and solvent-free pathway for creating injectable elastomers with tissue-mimetic softness. Currently, injectable materials involve solvents and chemical reactions, leading to uncontrolled swelling, leaching of unreacted moieties, and side reactions with tissue. To address this issue, bottlebrush copolymers with a poly(ethylene glycol) (PEG) amorphous block and crystallizable poly(lactic acid) (PLA) grafted chains (A--B) were synthesized, with grafted chains of controlled length arranged along the backbone at controlled spacing.
View Article and Find Full Text PDFSelf-powered Wraparound (Abaxial) Droplet Deposition via a Superhydrophobic Surface Aid.
J Agric Food Chem
January 2025
CAS Key Laboratory of Bio-inspired Materials and Interfacial Science, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences; Future Technology College, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100190, China.
Many diseases and pests are fond of the backs of leaves, making wraparound deposition essential for enhancing agrochemical utilization and minimizing environmental hazards. We present a superhydrophobic surface decorated with fluorinated-SiO nanoparticles on the adaxial (front) side, improving sprayed droplet wraparound behaviors and achieving a 10-fold increase in abaxial (backside) deposition without using an electrostatic sprayer. Solid-liquid contact electrification boosts the positive charge-to-mass ratio of rebound spraying from 17 to 454 nC g, with the abaxial surface acquiring opposite electric charges at kilovolt-level voltages.
View Article and Find Full Text PDFModulation of Molecular Quadrupole Moments by Phenyl Side-Chain Fluorination for High-Voltage and High-Performance Organic Solar Cells.
J Am Chem Soc
January 2025
College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China.
The ground-state charge generation (GSCG) in photoactive layers determines whether the photogenerated carriers occupy the deep trap energy levels, which, in turn, affects the device performance of organic solar cells (OSCs). In this work, charge-quadrupole electrostatic interactions are modulated to achieve GSCG through a molecular strategy of introducing different numbers of F atom substitutions on the BTA3 side chain. The results show that 8F substitution (BTA3-8F) and 16F substitution (BTA3-16F) lead to different patterns of highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) energy level changes.
View Article and Find Full Text PDFSignificant Efficiency Enhancements in Non-Y Series Acceptors by the Addition of Outer Side Chains.
Adv Sci (Weinh)
January 2025
Department of Chemistry and Centre for Processable Electronics, Imperial College London, London, W12 0BZ, UK.
Most current highly efficient organic solar cells utilize small molecules like Y6 and its derivatives as electron acceptors in the photoactive layer. In this work, a small molecule acceptor, SC8-IT4F, is developed through outer side chain engineering on the terminal thiophene of a conjugated 6,12-dihydro-dithienoindeno[2,3-d:2',3'-d']-s-indaceno[1,2-b:5,6-b']dithiophene (IDTT) central core. Compared to the reference molecule C8-IT4F, which lacks outer side chains, SC8-IT4F displays notable differences in molecule geometry (as shown by simulations), thermal behavior, single-crystal packing, and film morphology.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!