AI Article Synopsis
- Thyroid dysgenesis (TD) is the leading cause of congenital hypothyroidism in areas with sufficient iodine and presents a range of developmental issues.
- The genetic basis of TD is intricate, involving sporadic cases and unique monogenetic forms that do not follow simple Mendelian inheritance patterns.
- The article reviews thyroid development, highlights relevant genes and mechanisms of TD, and emphasizes the importance of modern genetic technologies for further research in this field.
Article Abstract
Thyroid dysgenesis (TD) is the most common cause of congenital hypothyroidism in iodine-sufficient regions and includes a spectrum of developmental anomalies. The genetic components of TD are complex. Although a sporadic disease, advances in developmental biology have revealed monogenetic forms of TD. Inheritance is not based on a simple Mendelian pattern and additional genetic elements might contribute to the phenotypic spectrum. This article summarizes the key steps of normal thyroid development and provides an update on responsible genes and underlying mechanisms of TD. Up-to-date technologies in genetics and biology will allow us to advance in our knowledge of TD.
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| http://dx.doi.org/10.1016/j.ecl.2016.01.007 | DOI Listing |
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