AI Article Synopsis
- The paper discusses a case of ineffective dual antiviral therapy in a patient with chronic hepatitis C, specifically HCV genotype 2.
- Analysis revealed that predictors for treatment failure included a specific HCV variant, high viral load, unfavorable genetic factors, obesity, and dose adjustments due to side effects.
- The authors recommend additional genetic testing when HCV genotype 2 is diagnosed to identify any recombinant strains, suggesting that direct-acting antiviral therapy may be more effective in these cases.
Article Abstract
The paper describes a case of ineffective dual antiviral therapy (pegylated interferon and ribavirin) in a patient with chronic hepatitis C infected with hepatitis C virus (HCV) genotype 2 according to the data from the use of a commercial test system. Analysis of the predictors of failure of antiviral therapy (AVT) (the HCV recombinant variant RF2k/1b, a high viral load before the start of therapy, an unfavorable IL-28B genotype, a high body mass index, and a need for a lower ribavirin dose after 12 weeks of AVT because of adverse reactions for less than 4 weeks) in this patient has shown that no virological response is mainly associated with the presence of the HCV recombinant variant, the treatment effectiveness of which is comparable with that in HCV genotype 1 and obesity. In this connection, when HCV genotype 2 is identified, sequencing the NS5B region of the HCV genome is additionally recommended to rule out the virus recombinant strain and, if it is detected, highly effective interferon-free therapy with direct-acting antivirals is indicated.
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| http://dx.doi.org/10.17116/terarkh201688584-85 | DOI Listing |
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