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| http://dx.doi.org/10.1016/j.dadm.2015.02.001 | DOI Listing |
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Stepwise identification of prodromal dementia: Testing a practical model for primary care.
J Alzheimers Dis
December 2024
Department of Counseling and School Psychology, University of Massachusetts Boston, Boston, MA, USA.
Article Synopsis
- Prodromal dementia is often missed in primary care, prompting a need for effective detection methods.
- The study created a clinical model using the Functional Activities Questionnaire (FAQ) and Montreal Cognitive Assessment (MoCA) to improve identification of early dementia stages.
- Results showed the proposed "step-down" screening model significantly outperformed alternative methods, suggesting it could efficiently support primary care in diagnosing dementia amidst growing treatment options and demand.
A 14-year longitudinal study of neurofilament light chain dynamics in premanifest and transitional Huntington's disease.
J Neurol
December 2024
Department of Clinical Neurosciences, John Van Geest Centre for Brain Repair, University of Cambridge, Cambridge, UK.
Article Synopsis
- Scientists studied a protein called neurofilament light (NfL) to see if it can help predict Huntington's disease (HD) over a long time.
- They collected blood samples from people with the HD gene and from healthy people over a 14-year period to compare NfL levels.
- The results showed that higher NfL levels were connected to a higher risk of developing symptoms of HD, and it could help identify who might get the disease earlier.
Can volumetric magnetic resonance imaging evaluations be helpful in the follow-up of cognitive functions in cognitively normal Parkinson's disease patients?
Turk J Med Sci
September 2024
Faculty of Medicine, İzmir University of Economics, İzmir, Turkiye.
Background/aim: In this study, besides the evaluation of gray and white matter changes in cognitively normal Parkinson's disease (PD-CN) patients with volumetric magnetic resonance imaging (MRI) parameters, it was tried to show that some neuropsychological tests may be impaired in PD-CN patients.
Materials And Methods: Twenty-six PD-CN patients and 26 healthy elderly (HC) participants were included in the current study. Global cognitive status was assessed using the mini-mental state examination (MMSE), and the Montreal cognitive assessment scale (MoCA).
Plasma level of alpha-synuclein oligomers as a biomarker for isolated rapid eye movement sleep behavior disorder diagnosis and progression: a prospective cohort study.
Front Neurol
August 2024
Department of Neurobiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Background: Alpha-synuclein oligomers (o-α-syn) are pivotal in the pathogenesis of α-synucleinopathy. Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) serves as an early indicator of the disease, offering insights into disease mechanisms and early intervention. Nevertheless, the diagnostic and predictive potential of o-α-syn in iRBD remains largely unexplored.
View Article and Find Full Text PDFImportance: Parkinson's disease (PD), the second most common neurodegenerative disease, is pathologically characterized by intraneuronal deposition of misfolded alpha-synuclein aggregates (αSyn ). αSyn seeding activities in CSF and skin samples have shown great promise in PD diagnosis, but they require invasive procedures. Sensitive and accurate αSyn seed amplification assay (αSyn-SAA) for more accessible and minimally invasive samples (such as blood and saliva) are urgently needed for PD pathological diagnosis in routine clinical practice.
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