AI Article Synopsis
- The study explores how gold nanoparticles can generate singlet oxygen when exposed to laser light, particularly through their plasmon resonance effects.
- Citrate-stabilized nanoparticles showed the ability to produce singlet oxygen, although the yield was relatively low, especially in pulsed laser setups that generate hot electrons.
- Continuous laser irradiation, while less efficient, can still produce enough singlet oxygen for cancer therapy, but requires careful design of the nanoparticles to optimize performance, as factors like capping layer thickness and nanoparticle size influence efficiency.
Article Abstract
The formation of singlet oxygen by irradiation of gold nanoparticles in their plasmon resonance band with continuous or pulsed laser light has been investigated. Citrate-stabilized nanoparticles were found to facilitate the photogeneration of singlet oxygen, albeit with low quantum yield. The reaction caused by pulsed laser irradiation makes use of the equilibrated hot electrons that can reach temperatures of several thousand degrees during the laser pulse. Although less efficient, continuous irradiation, which acts via the short-lived directly excited primary "hot" electrons only, can produce enough singlet oxygen for photodynamic cancer therapy and has significant advantages for practical applications. However, careful design of the nanoparticles is needed, since even a moderately thick capping layer can completely inhibit singlet oxygen formation. Moreover, the efficiency of the process also depends on the nanoparticle size.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878812 | PMC |
| http://dx.doi.org/10.1021/acs.jpcc.6b02005 | DOI Listing |
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