Put human beings together with movable and immovable objects, sharp and blunt instruments and there will always be accidents. They remain the most common.
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http://dx.doi.org/10.7748/ns.7.7.2.s72 | DOI Listing |
Drugs
January 2025
Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, UK.
The incidence of gastroesophageal cancers is rising, driven, in part, by an increasing burden of risk factors of obesity and gastroesophageal reflux. Despite efforts to address these risk factors, and a growing interest in methods of population screening, the bulk of these tumours are unresectable at diagnosis. In this setting, effective systemic treatments are paramount to improve survival and quality of life.
View Article and Find Full Text PDFEMBO Mol Med
January 2025
Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Nijmegen Medical Centre, 6500HB, Nijmegen, the Netherlands.
Recent studies argue for a novel concept of the role of chromatin as a carrier of epigenetic memory through cellular and organismal generations, defining and coordinating gene activity states and physiological functions. Environmental insults, such as exposures to unhealthy diets, smoking, toxic compounds, and infections, can epigenetically reprogram germ-line cells and influence offspring phenotypes. This review focuses on intergenerational and transgenerational epigenetic inheritance in different plants, animal species and humans, presenting the up-to-date evidence and arguments for such effects in light of Darwinian and Lamarckian evolutionary theories.
View Article and Find Full Text PDFAdv Nutr
January 2025
Department of Nephrology, The Scarborough Health Network, Toronto, Ontario, Canada; Kidney Life Sciences Institute, Toronto, Ontario, Canada.
Managing diabetes in patients on peritoneal dialysis (PD) is challenging due to the combined effects of dietary glucose, glucose from dialysate, and other medical complications. Advances in technology that enable continuous biological data collection are transforming traditional management approaches. This review explores how multi-omics technologies and artificial intelligence (AI) are enhancing glucose management in this patient population.
View Article and Find Full Text PDFJ Am Acad Child Adolesc Psychiatry
January 2025
UCLA Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California.
Diabetes Care
February 2025
Center for the Study of Aging and Human Development, Duke University, Durham, NC.
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