Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jcmg.2016.02.025 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Optimisation of low and ultra-low dose scanning protocols for ultra-extended field of view PET in a real-world clinical setting.
Cancer Imaging
January 2025
Melbourne Theranostic Innovation Centre, Level 8, 14-20 Blackwood St, North Melbourne, VIC, 3051, Australia.
True total-body and extended axial field-of-view (AFOV) PET/CT with 1m or more of body coverage are now commercially available and dramatically increase system sensitivity over conventional AFOV PET/CT. The Siemens Biograph Vision Quadra (Quadra), with an AFOV of 106cm, potentially allows use of significantly lower administered radiopharmaceuticals as well as reduced scan times. The aim of this study was to optimise acquisition protocols for routine clinical imaging with FDG on the Quadra the prioritisation of reduced activity given physical infrastructure constraints in our facility.
View Article and Find Full Text PDFPrevalence, incidence, and clinical features of cardiac involvement in patients with pulmonary sarcoidosis.
Respir Med
January 2025
Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan.
Background: The epidemiology and characteristics of cardiac involvement in patients with pulmonary sarcoidosis remain unclear. We aimed to determine the prevalence, incidence, and clinical features of cardiac sarcoidosis in patients with pulmonary sarcoidosis.
Methods: The characteristics of patients with biopsy-proven pulmonary sarcoidosis were retrospectively evaluated.
Inter-network functional connectivity increases by beta-amyloid and may facilitate the early stage of tau accumulation.
Neurobiol Aging
January 2025
Department of Radiology, Brain Health Imaging Institute, Weill Cornell Medicine, New York, NY, United States.
Alzheimer's disease (AD) is pathologically marked by tau tangles and beta-amyloid (Aβ) plaques. It has been hypothesized that Aβ facilitates spread of tau outside of the medial temporal lobe (MTL), but exact mechanism of this facilitation remains unclear. We aimed to test the hypothesis that abnormal Aβ induces an increase in inter-network functional connectivity, which in turn induces early-stage tau elevation in limbic network.
View Article and Find Full Text PDFPET Reporter Probes for Brain Imaging of Transduced Gene and Cell Expression: Status and Challenges.
J Med Chem
January 2025
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, 20892 United States.
Article Synopsis
- Gene therapy and cell transduction are emerging as promising treatments for neurological and psychiatric disorders, with PET imaging playing a key role in assessing treatment effectiveness.
- The success of PET imaging relies on the creation of specific radiotracers that can identify exogenous transgenes or modified cells in the brain, potentially eliminating the need for invasive procedures.
- This article discusses the current state and challenges in developing PET probes for monitoring gene therapy and cellular interventions, highlighting the importance of radiochemical development and practical applications in a clinical setting.
Preclinical evaluation of zirconium-89 labeled anti-Trop2 antibody-drug conjugate (Trodelvy) for imaging in gastric cancer and triple-negative breast cancer.
Eur J Nucl Med Mol Imaging
January 2025
Departments of Radiology and Medical Physics, University of Wisconsin - Madison, Madison, WI, 53705, USA.
Purpose: Trophoblast cell-surface antigen 2 (Trop2) is overexpressed in various solid tumors and contributes to tumor progression, while its expression remains low in normal tissues. Trop2-targeting antibody-drug conjugate (ADC), sacituzumab govitecan-hziy (Trodelvy), has shown efficacy in targeting this antigen. Leveraging the enhanced specificity of ADCs, we conducted the first immunoPET imaging study of Trop2 expression in gastric cancer (GC) and triple-negative breast cancer (TNBC) models using Zr-labeled Trodelvy ([Zr]Zr-DFO-Trodelvy).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!