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Mutation in Prkra results in cerebellar abnormality and reduced eIF2α phosphorylation in a model of DYT-PRKRA.
Dis Model Mech
November 2024
Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA.
Variants in the PRKRA gene, which encodes PACT, cause the early-onset primary dystonia DYT-PRKRA, a movement disorder associated with disruption of coordinated muscle movements. PACT and its murine homolog RAX activate protein kinase R (PKR; also known as EIF2AK2) by a direct interaction in response to cellular stressors to mediate phosphorylation of the α subunit of eukaryotic translation initiation factor 2 (eIF2α). Mice homozygous for a naturally arisen, recessively inherited frameshift mutation, Prkralear-5J, exhibit progressive dystonia.
View Article and Find Full Text PDFDevelopment and validation of a rapid loop-mediated isothermal amplification assay for the detection of Chrysomyxa and characterization of Chrysomyxa woroninii overwintering on Picea in China.
IMA Fungus
August 2024
Beijing Key Laboratory for Forest Pest Control, Beijing Forestry University, Beijing, 100083, China.
Chrysomyxa rusts cause significant damage to spruce in both natural forests and plantations. Particularly, Three Chrysomyxa species, Chrysomyxa deformans, Chrysomyxa qilianensis, and Chrysomyxa rhododendri, listed as National Forest Dangerous Pests in China, have severely affected many economically and ecologically important spruce native species in China. Also, Chrysomyxa arctostaphyli, an important plant quarantine fungus, causes a damaging broom rust disease on spruce.
View Article and Find Full Text PDFThe Decline of Paget's Disease of Bone and Domestic Coal Use-A Hypothesis.
Calcif Tissue Int
August 2024
Faculty of Medical & Health Sciences, University of Auckland, Auckland, Aotearoa New Zealand.
The cause of Paget's disease of bone (PDB) is unknown. It emerged as a distinct entity in Britain in the late nineteenth century when it was prevalent, and florid presentation not uncommon. Epidemiological surveys in the 1970s showed that Britain had a substantially higher prevalence of PDB than any other country.
View Article and Find Full Text PDFControl of Peach Leaf Curl with Foliar Applications of Plant Immunity Inducers and Insights in Elicitation of Defense Responses against .
J Fungi (Basel)
April 2024
Hellenic Agricultural Organization-DIMITRA (ELGO-DIMITRA), Institute of Plant Breeding and Genetic Resources, 57001 Thessaloniki, Greece.
is the causal agent of leaf curl, a serious peach disease which causes significant losses in peach production worldwide. Nowadays, in order to control plant diseases, it is necessary to adopt novel and low-cost alternatives to conventional chemical fungicides. These promising strategies are targeted at eliciting host defense mechanisms via priming the host through the consecutive application of plant immunity inducers prior to pathogen challenge.
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