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Tubulin tyrosination/detyrosination regulate the affinity and sorting of intraflagellar transport trains on axonemal microtubule doublets.
Nat Commun
January 2025
Cluster of Excellence Physics of Life, TUD Dresden University of Technology, 01062, Dresden, Germany.
Cilia assembly and function rely on the bidirectional transport of components between the cell body and ciliary tip via Intraflagellar Transport (IFT) trains. Anterograde and retrograde IFT trains travel along the B- and A-tubules of microtubule doublets, respectively, ensuring smooth traffic flow. However, the mechanism underlying this segregation remains unclear.
View Article and Find Full Text PDFAssociation between the hemoglobin A1c/High-density lipoprotein cholesterol ratio and stroke incidence: a prospective nationwide cohort study in China.
Lipids Health Dis
January 2025
Department of Neurosurgery, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, 213000, China.
Background: Stroke has emerged as an escalating public health challenge among middle-aged and older individuals in China, closely linked to glycolipid metabolic abnormalities. The Hemoglobin A1c/High-Density Lipoprotein Cholesterol (HbA1c/HDL-C) ratio, an integrated marker of glycolipid homeostasis, may serve as a novel predictor of stroke risk.
Methods: Our investigation utilized data from the China Health and Retirement Longitudinal Study cohort (2011-2018).
A Transformer Encoder Approach for Localization Reconstruction During GPS Outages from an IMU and GPS-Based Sensor.
Sensors (Basel)
January 2025
Haute Ecole de Gestion Genève, HES-SO, 1227 Carouge, Switzerland.
Accurate localization is crucial for numerous applications. While several methods exist for outdoor localization, typically relying on GPS signals, these approaches become unreliable in environments subject to a weak GPS signal or GPS outage. Many researchers have attempted to address this limitation, primarily focusing on real-time solutions.
View Article and Find Full Text PDFInvestigation of Sliding Mode Control in the Nonlinear Modeling of Cordless Jigsaws.
Sensors (Basel)
January 2025
Department of Electrical Engineering and Mechatronics, Faculty of Engineering, Vehicles and Mechatronics Institute, University of Debrecen, Ótemető Str. 2-4., H-4028 Debrecen, Hungary.
The aim of this paper was to reduce the current spikes in battery-powered saw motors by designing and implementing a sliding mode model-following adaptive controller. The proposed controller reduces overcurrent consumption, improves system energy efficiency, and effectively maximizes battery runtime, especially under high-load conditions. By applying nonlinear compensation techniques, the controller can ensure smooth motor operation, reduce mechanical stress, and prolong tool life.
View Article and Find Full Text PDFAutomated Volumetric Milling Area Planning for Acoustic Neuroma Surgery via Evolutionary Multi-Objective Optimization.
Sensors (Basel)
January 2025
School of Biomedical Engineering, Tsinghua University, Shuang Qing Road, Beijing 100084, China.
Mastoidectomy is critical in acoustic neuroma surgery, where precise planning of the bone milling area is essential for surgical navigation. The complexity of representing the irregular volumetric area and the presence of high-risk structures (e.g.
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