Aim: The objective of the study is to describe the characteristics of subjects under opiate maintenance treatment by general practionners (GPs).
Method: Data analysis from observatory for pharmacodependency in ambulatory medicine survey (observation des pharmacodépendances en médecine ambulatoire [OPEMA]) program in 2013 of the subjects under high dosage buprenorphine (HDB) and methadone prescribed or obtained illegally reported by GPs in France.
Results: Survey concerned consumers with 862, 433 and 429 of high dosage buprenorphine and respectively methadone. The average age is 39±9 years respectively, and 36±8 years; over 70% are male; 55% have paid employment and over 30% report social benefits; 9% are in temporary housing. In both groups, more than 50% have anxiety and depression; over 25% have associated somatic disorders and digestive diseases, respiratory, pain is the most common. Almost 99% use oral route; nearly 100% have a daily consumption and about 20% of the alcohol concomitantly; 24% of HDB use benzodiazepines and 18% of the methadone group (P=0.06); 33% of the population using methadone consume illicit psychoactive substances and 21% for HDB population (P<0.0001), in particular cannabis (P<0.0001). Heroin and cocaine are also consumed.
Conclusion: The population consuming opiate maintenance treatments shows social, somatic and psychiatric vulnerability. Misuse associated forms and consumption of other psychoactive substances and illegal drugs are observed. Despite the complexity of management of these patients, general practitioners have a major role to play.
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http://dx.doi.org/10.1016/j.therap.2016.02.001 | DOI Listing |
Neurol Sci
December 2024
Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA, 02115, USA.
Gastrointest Endosc
December 2024
Division of Gastroenterology and Hepatology University of Colorado Anschutz Medical Campus, Aurora, Colorado. Electronic address:
Background And Aims: Pancreatic endotherapy (PET) offers a treatment option for complications of chronic pancreatitis (CP) such as pancreatic duct (PD) strictures, stones, and pseudocysts. As prior studies have primarily focused on how PET affects pain, the primary aim of this study was to evaluate the effect of PET on quality of life.
Methods: This single-center prospective study assessed quality of life before the initiation of endotherapy utilizing a validated CP-specific quality of life instrument (PANQOLI).
Cureus
November 2024
Trauma and Orthopaedics, Calderdale and Huddersfield NHS Foundation Trust, Huddersfield, GBR.
Introduction Tourniquets are commonly used when performing total knee arthroplasty (TKA) to reduce intra-operative blood loss, improve surgical field visibility, and potentially improve cement penetration during prosthesis implantation. However, they may be associated with increased thigh pain, postoperative opiate use, and longer lengths of hospital stay. Methods Retrospectively collected data was obtained from our institution's electronic patient records and database.
View Article and Find Full Text PDFBMJ Open
December 2024
Department of Anesthesiology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China
Introduction: The neuraxial morphine has been regarded as the gold standard for postpartum analgesia. However, the recent advancements in patient-controlled analgesia and various regional nerve blocks have led to the implementation of multimodal analgesia strategies, which aim to reduce opioid usage and associated complications while ensuring satisfactory pain relief. The objective of this research is to investigate the optimal dosage of epidural morphine for alleviating moderate and severe pain after caesarean sections in healthy parturients, as well as reducing unnecessary burden of respiratory monitoring resources.
View Article and Find Full Text PDFDev Psychobiol
January 2025
Department of Comparative Pathobiology, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA.
Methadone and buprenorphine are commonly prescribed during pregnancy to maintain recovery and prevent symptoms of withdrawal in women with opioid use disorder. Infants prenatally exposed to medications for opioid use disorder (MOUD), however, commonly show signs of neonatal opioid withdrawal syndrome (NOWS), which can include feeding-related issues like hyperphagia. To investigate the effects of prenatal MOUD exposure on feeding behavior, female Sprague-Dawley rats were implanted with osmotic minipumps filled with methadone, buprenorphine, or saline and subsequently mated.
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