Objectives: This work describes the bioguided fractionation of the flower's ethyl acetate fraction of Scabiosa arenaria Forssk. (Dipsacaceae).
Methods: The identification of the pure compound isolated has been studied by mono-dimensional NMR experiments. The mixture of phenolic compounds was analysed by LC-ESI-MS/MS. The antioxidant activity has been evaluated by the 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay.
Key Findings: The bioguided fractionation of the flower's ethyl acetate fraction of Scabiosa arenaria led to the isolation of a pure compound: luteolin. The mixture of three phenolic compounds was identified as: 1, 4-O-dicaffeoylquinic acid, apigenin 7-O-glucoside and luteolin-7-O-glucoside. Two of which are reported here for the first time in Scabiosa genus. Luteolin had the highest antioxidant activity with an IC50 value of 0.02 ± 0.007 mg/ml, followed by the three phenolic compounds with an IC50 value of 0.025 ± 0.008 mg/ml.
Conclusions: The results of the present work indicate that S. arenaria flower's ethyl acetate extract could be used as natural antioxidant agents in food preservation and human health.
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