Thermal enhancement of cis-diamminedichloroplatinum (II) (DDP) induced renal and intestinal toxicities by whole body hyperthermia (WBH) were compared using a F344 rat model. Thermal enhancement ratios (TER) for DDP-induced nephrotoxicity were calculated using renal functional assays and morphological techniques. TER values for gastrointestinal (G.I.) toxicity were calculated using "severity of diarrhea" and jejunal crypt cell survival as assays. TER's for renal damage varied between 3 and 3.4, whereas the TER measured for G.I.-toxicity was 1.8. Physiological changes caused by WBH or intrinsic differences in the sensitivities of normal tissues to DDP +/- WBH may be responsible for the differences in thermal enhancement of DDP-induced renal and intestinal toxicities.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0360-3016(89)90961-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Preserving pulp vitality for teeth with post-vital pulp therapy symptoms by retrying pulp-preserving procedures: A retrospective clinical study.
J Dent Sci
January 2025
Department of Conservative Dentistry, Kyung Hee University Dental Hospital at Gang-dong, Seoul, Republic of Korea.
Background/purpose: The occurrence of post-vital pulp therapy (VPT) symptoms is perplexing for dentists, and root canal treatment (RCT) is preferred for such conditions. Furthermore, managing post-VPT symptoms, rather than performing RCT, would preserve pulp vitality and enhance VPT outcomes. This study aimed to evaluate the efficacy of VPT retrials in preserving pulp vitality and substituting RCT in teeth with post-VPT symptoms.
View Article and Find Full Text PDFBreaking barriers: Elevating legume protein functionality in food products through non-thermal technologies.
Food Chem X
January 2025
Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming, 650500, China.
Legume proteins have recently gained significant interest in the food industry for their eco-friendliness and nutritional qualities. Research shows that the replacement of specific animal protein sources with legume proteins presents sustainability and economic benefit. Nonetheless, legume proteins frequently exhibit inferior functional properties and palatability compared to animal proteins.
View Article and Find Full Text PDFMicrowave ablation for liver metastases from colorectal cancer: A comprehensive review of clinical efficacy and safety.
World J Gastrointest Surg
January 2025
Department of Hepatopancreatobiliary Surgery, Chongqing General Hospital, Chongqing 401147, China.
Microwave ablation (MWA) is emerging as a highly effective treatment for colorectal liver metastases (CRLMs). This review explores the advantages of MWA compared to other ablative techniques such as radiofrequency ablation and cryoablation and highlights its clinical efficacy, safety, and technical considerations. MWA offers significant benefits, including higher intratumoral temperatures, larger ablation zones, and reduced susceptibility to the heat-sink effect, which make it particularly suitable for tumors near large blood vessels.
View Article and Find Full Text PDFAdsorption and Separation by Flexible MOFs.
Adv Mater
January 2025
Chair of Inorganic Chemistry I, Technische Universität Dresden, Bergstrasse 66, 01069, Dresden, Germany.
Flexible metal-organic frameworks (MOFs) offer unique opportunities due to their dynamic structural adaptability. This review explores the impact of flexibility on gas adsorption, highlighting key concepts for gas storage and separation. Specific examples demonstrate the principal effectiveness of flexible frameworks in enhancing gas uptake and working capacity.
View Article and Find Full Text PDFElucidating Mesostructural Effects on Thermal Conductivity for Enhanced Insulation Applications.
Small
January 2025
Laboratory of Advanced Materials, Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, State Key Laboratory of Molecular Engineering of Polymers, Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai, 200433, China.
Thermal management is a key link in improving energy utilization and preparing insulation materials with excellent performance is the core technological issue. Complex and irregular pore structures of insulation materials hinder the exploration of structure-property relationships and the further promotion of material performance. Ordered mesoporous silica (OMS) is a kind of porous material with ordered frameworks.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!