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Natural killer cell biology and therapy in multiple myeloma: challenges and opportunities.
Exp Hematol Oncol
November 2024
Research and Development, Sanofi, Cambridge, MA, 02141, USA.
Article Synopsis
- Multiple myeloma (MM) is currently incurable, but natural killer (NK) cells show potential as a treatment option due to their role in targeting tumor cells.
- NK cells vary in their characteristics (like surface markers) and effectiveness, with certain subsets being linked to better patient outcomes, especially in relation to disease stages.
- Current MM treatments can influence NK cell behavior, suggesting that combining NK cell enhancements with existing therapies may improve overall treatment effectiveness.
Observation of Medium-Induced Yield Enhancement and Acoplanarity Broadening of Low-p_{T} Jets from Measurements in pp and Central Pb-Pb Collisions at sqrt[s_{NN}]=5.02 TeV.
Phys Rev Lett
July 2024
INFN, Sezione di Pavia, Pavia, Italy.
The ALICE Collaboration reports the measurement of semi-inclusive distributions of charged-particle jets recoiling from a high transverse momentum (high p_{T}) hadron trigger in proton-proton and central Pb-Pb collisions at sqrt[s_{NN}]=5.02 TeV. A data-driven statistical method is used to mitigate the large uncorrelated background in central Pb-Pb collisions.
View Article and Find Full Text PDFTumor-associated NK cells drive MDSC-mediated tumor immune tolerance through the IL-6/STAT3 axis.
Sci Transl Med
May 2024
Department of Oncology-Pathology, Karolinska Institutet, 17164 Stockholm, Sweden.
Apart from their killer identity, natural killer (NK) cells have integral roles in shaping the tumor microenvironment. Through immune gene deconvolution, the present study revealed an interplay between NK cells and myeloid-derived suppressor cells (MDSCs) in nonresponders of immune checkpoint therapy. Given that the mechanisms governing the outcome of NK cell-to-myeloid cell interactions remain largely unknown, we sought to investigate the cross-talk between NK cells and suppressive myeloid cells.
View Article and Find Full Text PDFFunctional connectivity in rumination: a systematic review of magnetic resonance imaging studies.
J Clin Exp Neuropsychol
November 2023
Department of Psychiatry, Baskent University Faculty of Medicine, Ankara, Turkey.
Introduction: Rumination, defined as intrusive and repetitive thoughts in response to negative emotions, uncertainty, and inconsistency between goal and current situation, is a significant risk factor for depressive disorders. The rumination literature presents diverse findings on functional connectivity and shows heterogeneity in research methods. This systematic review seeks to integrate these findings and provide readers diverse perspectives.
View Article and Find Full Text PDFBeyond traditional therapies: clinical significance of complex molecular profiling in patients with advanced solid tumours-results from a Turkish multi-centre study.
Jpn J Clin Oncol
May 2024
Medical Oncology, Inonu University Faculty of Medicine, Malatya, Turkey.
Objective: The objective of this multi-centre, real-world study was to examine the potential influence of comprehensive molecular profiling on the development of treatment decisions or adjustments for patients with advanced solid malignancies. We then evaluated the impact of these informed choices on patient treatment outcomes.
Methods: The study encompassed 234 adult patients (mean age: 52.
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