Filoviruses have become a worldwide public health concern because of their potential for introductions into non-endemic countries through international travel and the international transport of infected animals or animal products. Since it was first identified in 1976, in the Democratic Republic of Congo (formerly Zaire) and Sudan, the 2013-2015 western African Ebola virus disease (EVD) outbreak is the largest, both by number of cases and geographical extension, and deadliest, recorded so far in medical history. The source of ebolaviruses for human index case(s) in most outbreaks is presumptively associated with handling of bush meat or contact with fruit bats. Transmission among humans occurs easily when a person comes in contact with contaminated body fluids of patients, but our understanding of other transmission routes is still fragmentary. This review deals with the controversial issue of aerosol transmission of filoviruses.
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http://dx.doi.org/10.3390/v8050148 | DOI Listing |
Anesth Crit Care
October 2024
Department of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona CA 91766, USA.
Anesthesiologists and the critical care team may be at increased risk of contracting severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2, COVID-19) due to airway manipulations and intubations performed during anesthesia administration and management of patient undergoing surgery. SARS-CoV-2 infections have been reported among healthcare workers. The virus is transmitted by close personal contact and aerosols.
View Article and Find Full Text PDFEClinicalMedicine
January 2025
WEISS Centre, University College London, UK.
Background: The COVID-19 pandemic highlighted the need for improved infectious aerosol concentrations through interventions that reduce the transmission of airborne infections. The aims of this review were to map the existing literature on interventions used to improve infectious aerosol concentrations in hospitals and understand challenges in their implementation.
Methods: We reviewed peer-reviewed articles identified on three databases, MEDLINE, Web of Science, and the Cochrane Library from inception to July 2024.
J Phys Chem A
January 2025
School of Chemistry, University of Bristol, Bristol BS8 1TS, U.K.
In both nature and industry, aerosol droplets contain complex mixtures of solutes, which in many cases include multiple inorganic components. Understanding the drying kinetics of these droplets and the impact on resultant particle morphology is essential for a variety of applications including improving inhalable drugs, mitigating disease transmission, and developing more accurate climate models. However, the previous literature has only focused on the relationship between drying kinetics and particle morphology for aerosol droplets containing a single nonvolatile component.
View Article and Find Full Text PDFJ Virol
January 2025
Microbiology and Immunology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA.
Measles virus (MeV) is a highly contagious respiratory virus transmitted via aerosols. To understand how MeV exits the airways of an infected host, we use unpassaged primary cultures of human airway epithelial cells (HAE). MeV typically remains cell-associated in HAE and forms foci of infection, termed infectious centers, by directly spreading cell-to-cell.
View Article and Find Full Text PDFHeart Lung
January 2025
Programa de Pós-Graduação em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul - Rua Ramiro Barcelos, 2350, Sala 2050, CEP 90035-003, Porto Alegre, RS, Brazil; Unidade de Fisiologia Pulmonar, Hospital de Clínicas de Porto Alegre - Rua Ramiro Barcelos, 2350, Sala 2050, CEP 90035-003, Porto Alegre, RS, Brazil.
Background: Pulmonary function testing (PFT) is paramount in assessing patients with respiratory symptoms and chronic cardiopulmonary diseases. Although seminal studies have demonstrated that PFT generates aerosols, this simple observation does not confirm the potential for enhanced pathogen transmission.
Objective: We aimed to describe the frequency of patients who developed suspected symptoms of COVID-19, prompting SARS-CoV-2 testing after undergoing PFT during the reopening of a laboratory amid the deceleration of the pandemic.
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