AI Article Synopsis
- This study investigated how Electronic Cigarette (EC) aerosols behave using advanced technology, revealing that longer puff durations lead to higher particle concentrations in the gas phase.
- The size of nanoparticles in EC aerosols was found to be larger in liquid media compared to gas, possibly due to aggregation.
- In vitro experiments showed that EC aerosols lower glutathione levels in oral epithelial cells, indicating that they can cause cell damage partly due to oxidative stress from harmful substances in the aerosols.
Article Abstract
In this study, we have generated and characterized Electronic Cigarette (EC) aerosols using a combination of advanced technologies. In the gas phase, the particle number concentration (PNC) of EC aerosols was found to be positively correlated with puff duration whereas the PNC and size distribution may vary with different flavors and nicotine strength. In the liquid phase (water or cell culture media), the size of EC nanoparticles appeared to be significantly larger than those in the gas phase, which might be due to aggregation of nanoparticles in the liquid phase. By using in vitro high-throughput cytotoxicity assays, we have demonstrated that EC aerosols significantly decrease intracellular levels of glutathione in NHOKs in a dose-dependent fashion resulting in cytotoxicity. These findings suggest that EC aerosols cause cytotoxicity to oral epithelial cells in vitro, and the underlying molecular mechanisms may be or at least partially due to oxidative stress induced by toxic substances (e.g., nanoparticles and chemicals) present in EC aerosols.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880184 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0154447 | PLOS |
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