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Clinical course for pancreatic necrosis and pancreatic pseudocysts due to severe acute or chronic pancreatitis.

Therap Adv Gastroenterol

November 2024

Section of Gastroenterology, Gastrointestinal Oncology, Hepatology, Infectiology and Geriatrics, Department of Internal Medicine I, University Hospital of Tübingen, Tübingen, Germany.

Background: The acute and chronic pancreatitis (CP) can lead to severe complications like walled-off necrosis, large symptomatic pseudocyst or multiorgan failure. The treatment of these complications is multivariate and can differ from conservative, symptomatic treatment or minimal-invasive, endoscopic transgastral stenting to transgastral necrosectomy.

Objectives: This study aims to analyse the clinical course for patients that develop local complications of severe pancreatitis.

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The review is devoted to transgastric necrectomy in the treatment of infected forms of acute pancreatitis. The authors discuss the indications for transgastric necrectomy and technical features of these interventions (direct endoscopic necrectomy, laparoscopic and open transgastric necrectomy). Numerous studies devoted to results of transgastric necrectomy indicate advisability of this procedure in carefully selected patients and interdisciplinary interaction of various specialists before and after surgery.

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Article Synopsis
  • - The study investigated outcomes of lumen-apposing metal stents (LAMS) placement in patients with surgically altered anatomy (SAA), which is not well-documented in existing literature, involving 270 patients across 25 tertiary care centers up to November 2023.
  • - Technical success of the procedures was very high at 98%, with clinical success at 97%, although there was a notable adverse event rate of 12%, with various degrees of severity recorded.
  • - The results suggest that while LAMS placement in SAA is effective, due to the risk of complications, these procedures should only be performed by experienced endoscopists in specialized centers.
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