AI Article Synopsis
- Addiction to methamphetamine is a major public health concern in the U.S., with no FDA-approved treatments currently available.
- Researchers identified a specific region on chromosome 11 that impacts sensitivity to methamphetamine using specially bred mice with varying sensitivities.
- By analyzing brain tissue, they aimed to uncover the biological mechanisms behind this sensitivity, and their findings are available in the NCBI Gene Expression Omnibus database.
Article Abstract
Addiction to psychostimulants such as Methamphetamine (MA) is a significant public health issue in the United States and currently, there are no FDA approved pharmacological interventions. Previously, using short term-selected mouse lines for high and low MA sensitivity that were derived from an F2 cross between C57BL/6J (B6) and DBA/2J (D2) strains, we identified a quantitative trait locus (QTL) on chromosome (chr) 11 that influenced sensitivity to MA-induced locomotor activity (D2 < B6). Using interval-specific murine congenic lines containing various D2 allelic segments on a B6 background, we fine mapped the QTL to a 206 kb critical interval on chromosome 11. To investigate the neurobiological mechanism by which this QTL decreases MA sensitivity, we conducted transcriptome analysis in a 10 Mb congenic mouse (chromosome 11: 50-60 Mb) on whole-striatum brain tissue punches compared to wild-type B6 littermate controls [1]. The data from this study can be found in the NCBI Gene Expression Omnibus (GSE66366).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856813 | PMC |
| http://dx.doi.org/10.1016/j.gdata.2016.03.009 | DOI Listing |
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