AI Article Synopsis
- A tradeoff in animal locomotion exists between regular movements for long-distance travel and flexible movements for local exploration.
- C. elegans has a posture control system that balances these needs, allowing the worm to switch between consistent undulations and flexible turning based on sensory inputs.
- Specific interneurons (AVK and DVA) and neuropeptides (FLP-1 and NLP-12) regulate these movement modes, highlighting the complexity of how simple nervous system features can lead to intricate, goal-directed locomotion strategies.
Article Abstract
In animal locomotion a tradeoff exists between stereotypy and flexibility: fast long-distance travelling (LDT) requires coherent regular motions, while local sampling and area-restricted search (ARS) rely on flexible movements. We report here on a posture control system in C. elegans that coordinates these needs. Using quantitative posture analysis we explain worm locomotion as a composite of two modes: regular undulations versus flexible turning. Graded reciprocal regulation of both modes allows animals to flexibly adapt their locomotion strategy under sensory stimulation along a spectrum ranging from LDT to ARS. Using genetics and functional imaging of neural activity we characterize the counteracting interneurons AVK and DVA that utilize FLP-1 and NLP-12 neuropeptides to control both motor modes. Gradual regulation of behaviors via this system is required for spatial navigation during chemotaxis. This work shows how a nervous system controls simple elementary features of posture to generate complex movements for goal-directed locomotion strategies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880447 | PMC |
| http://dx.doi.org/10.7554/eLife.14116 | DOI Listing |
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