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| http://dx.doi.org/10.1016/j.jamda.2016.04.009 | DOI Listing |
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Intravesical GG versus Saline Bladder Wash: Protocol for a Randomized, Controlled, Comparative Effectiveness Clinical Trial.
Top Spinal Cord Inj Rehabil
December 2022
Collaborative for Research on Outcomes and Metrics, and Departments of Neurology, Biostatistics, Bioinformatics & Biomathematics, and Rehabilitation Medicine, Georgetown University, Washington, DC.
Article Synopsis
- cUTI is a common issue for individuals with spinal cord injuries and neurogenic bladder dysfunction, leading to significant healthcare costs and complications.
- The study aims to compare the effectiveness of a self-administered intravesical LGG against saline bladder wash for managing urinary symptoms in 120 participants with SCIs for over six months, involving distinct treatment and prophylaxis phases.
- Results will focus on various patient-reported outcomes related to urinary symptoms, usage of antibiotics, and overall patient engagement, suggesting that this research design can inform future studies on cUTI management.
Intravesical is safe and well tolerated in adults and children with neurogenic lower urinary tract dysfunction: first-in-human trial.
Ther Adv Urol
October 2019
Collaborative for Research on Outcomes and Metrics and Departments of Neurology and Biostatistics, Bioinformatics & Biomathematics, Georgetown University Medical Center, Washington, DC, USA.
Background: Urinary symptoms are common for people with neurogenic lower urinary tract dysfunction (NLUTD). No nonprescription approach has been proven safe and effective for self-management of urinary symptoms. Our objective was to describe the safety and tolerability of (®) instilled intravesically for self-management of inflammatory urinary symptoms in adults and children with NLUTD due to spinal cord injury or disease (SCI/D) and who use intermittent catheterization (IC).
View Article and Find Full Text PDFNeomycin-polymyxin or gentamicin bladder instillations decrease symptomatic urinary tract infections in neurogenic bladder patients on clean intermittent catheterization.
J Pediatr Urol
April 2019
Department of Urology, David Geffen School of Medicine at UCLA, 300 Stein Plaza, 3rd Floor, Suite 331, Los Angeles, CA 90095, USA.
Introduction: Recurrent urinary tract infections (UTIs) are common in patients with neurogenic bladder (NGB) performing clean intermittent catheterization (CIC) treated with or without oral antibiotic prophylaxis.
Objective: The authors aim to determine if daily neomycin-polymyxin or gentamicin bladder instillations reduce the rate of symptomatic UTIs, the need for oral antibiotic prophylaxis, emergency department (ED) visits for UTI, and inpatient hospitalizations for UTI in patients with NGB on CIC. The authors also aim to investigate resistance patterns in urine microorganisms in patients treated with antibiotic bladder instillations.
Enhancing quality practice for prevention and diagnosis of urinary tract infection during inpatient spinal cord rehabilitation.
J Spinal Cord Med
November 2017
a 1 Neural Engineering and Therapeutic Team, Lyndhurst Centre , UHN-Toronto Rehabilitation Institute.
Objectives: To reduce the incidence of Urinary Tract Infection (UTI) in subacute SCI individuals admitted for tertiary inpatient rehabilitation.
Design: A quality improvement team was assembled to improve UTI prevention/diagnosis. To plan data collection, UTI-related factors were mapped in an Ishikawa (fishbone) driver diagram.
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