AI Article Synopsis
- Ischemia-modified albumin (IMA) is a potential marker for detecting myocardial ischemia, and the study aimed to analyze its effectiveness following exercise-induced stress.
- Researchers measured IMA levels in 43 patients with confirmed coronary artery disease and a control group of 22 healthy individuals at various time points after exercise, finding significant differences in IMA kinetics between the two groups.
- While a specific timing for peak IMA levels was not determined due to variability, IMA showed promising diagnostic sensitivity (81%) and specificity (82%) for identifying myocardial ischemia, suggesting its utility in unclear cases.
Article Abstract
Background: Ischemia-modified albumin (IMA) is a potentially valuable biochemical marker of myocardial ischemia. The aim of our study was to define the kinetics and to determine the diagnostic value of IMA in detection of myocardial ischemia by using a model of exercise-stress induced transitory ischemia.
Methods: The study included 43 consecutive patients with positive exercise stress test and coronary artery disease confirmed by coronary angiography (ischemic group) and 22 healthy volunteers with negative exercise stress test (control group). IMA plasma levels were measured before and at nine time points after exercise over a 6-hour period.
Results: IMA kinetics was significantly different between the ischemic and control group (p = 0.03). In the ischemic group, IMA plasma levels peaked between the 3rd and 4th hour after exercise. However, due to large interindividual differences in the time-to-peak IMA values, a standard IMA kinetics curve could not be defined for the patients with transitory myocardial ischemia. On the other hand, with the cutoff value of a 10.6% relative increase, sensitivity and specificity of IMA for the detection of myocardial ischemia were sufficiently high at 81% and 82%, respectively.
Conclusions: Although an optimum time for the detection of recent myocardial ischemia by a single IMA sampling could not be defined, serial measurements of IMA can be a useful biochemical tool for the detection of myocardial ischemia in patients with doubtful exercise stress test results.
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| http://dx.doi.org/10.7754/clin.lab.2015.150732 | DOI Listing |
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