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Rapid and Slow Progressors Show Increased IL-6 and IL-10 Levels in the Pre-AIDS Stage of HIV Infection. | LitMetric

AI Article Synopsis

  • Cytokines play a crucial role in the progression of HIV, with plasma levels evaluated in extreme progressors (slow and rapid) before starting HIV treatment (HAART).
  • Significant differences were found in the levels of IL-6 and IL-10 across different HIV infection stages, with elevated levels in slow progressors before starting HAART compared to other groups.
  • These findings suggest that increased IL-6 and IL-10 levels may serve as indicators of inflammation and potentially reflect the disease progression in HIV-infected individuals, regardless of their progression status.

Article Abstract

Cytokines are intrinsically related to disease progression in HIV infection. We evaluated the plasma levels of Th1/Th2/Th17 cytokines in extreme progressors, including slow (SPs) and rapid (RPs) progressors, who were thus classified based on clinical and laboratory follow-up covering a period of time before the initiation of HAART, ranging from 93-136.5 months for SPs and 7.5-16.5 months for RPs. Analyses were also performed based on the different stages of HIV infection (chronic, pre-HAART individuals-subjects sampled before initiating HAART but who initiated therapy from 12 to 24 months-and those receiving HAART). The plasma cytokine levels of 16 HIV-infected rapid progressors and 25 slow progressors were measured using a Human Th1/Th2/Th17 CBA kit. The IL-6 and IL-10 plasma levels differed significantly between the stages of HIV infection. The IL-6 levels were higher in slow progressors pre-HAART than in chronically infected SPs and HIV-seronegative individuals. The IL-10 levels were higher in slow progressors pre-HAART than in slow progressors receiving HAART and HIV-seronegative controls, and in rapid progressors, the IL-10 levels were higher in pre-HAART subjects than in HIV-seronegative controls. The results reflect the changes in the cytokine profile occurring during different clinical stages in HIV+ subjects. Our results suggest an association between increased IL-6 and IL-10 levels and pre-HAART stages independent of the slow or rapid progression status of the subjects. Thus, increased IL-6 and IL-10 levels could indicate a global inflammatory status and could be used as markers of the disease course in HIV-infected individuals.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877004PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0156163PLOS

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