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| http://dx.doi.org/10.1177/2325967116644585 | DOI Listing |
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Alone or in combination, hyaluronic acid and chondroitin sulfate alleviate ECM degradation in osteoarthritis by inhibiting the NF-κB pathway.
J Orthop Surg Res
January 2025
Monash Suzhou Research Institute, Monash University, Suzhou, 215000, Jiangsu, China.
Backgrounds: Osteoarthritis (OA) significantly impacts the elderly, leading to disability and decreased quality of life. While hyaluronic acid (HA) and chondroitin sulfate (CS) are recognized for their therapeutic potential in OA, their effects on extracellular matrix (ECM) degradation are not well understood. This study investigates the impact of HA and CS, individually and combined, on ECM degradation in OA and the underlying mechanisms.
View Article and Find Full Text PDFCD206+ Trem2+ macrophage accumulation in the murine knee joint after injury is associated with protection against post-traumatic osteoarthritis in MRL/MpJ mice.
PLoS One
January 2025
Lawrence Livermore National Laboratory, Physical and Life Science Directorate, Livermore, CA, United States of America.
Post-traumatic osteoarthritis (PTOA) is a painful joint disease characterized by the degradation of bone, cartilage, and other connective tissues in the joint. PTOA is initiated by trauma to joint-stabilizing tissues, such as the anterior cruciate ligament, medial meniscus, or by intra-articular fractures. In humans, ~50% of joint injuries progress to PTOA, while the rest spontaneously resolve.
View Article and Find Full Text PDFExploring Rehabilitation Protocols for Primary Anterior Cruciate Ligament Repair: Insights from a Scoping Review.
Am J Phys Med Rehabil
January 2025
Department of Physical and Rehabilitation Medicine, Hacettepe University Medical School, Ankara, Turkey.
Objectives: The primary repair of the anterior cruciate ligament (ACL) has re-emerged as a treatment for acute ruptures. While numerous studies have investigated rehabilitation after ACL reconstruction, few have focused on primary repair. We aimed to describe the rehabilitation protocols for primary ACL repair, and to identify knowledge gaps and differences between primary ACL repair and reconstruction.
View Article and Find Full Text PDFSport-specific differences in ACL injury, treatment and return to sports: Basketball.
Knee Surg Sports Traumatol Arthrosc
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Division of Neurosciences and Musculoskeletal Diseases, Department of Orthopaedic Surgery, Centre Hospitalier de Luxembourg (CHL), Luxembourg, Luxembourg.
Basketball is an intense, fast-paced game that is physically, highly demanding. Certain aspects of the game, such as the quick pivoting and cutting movements, predispose the players to serious knee injuries, including anterior cruciate ligament (ACL) tears. While an ACL tear can be a devastating condition for players, multidisciplinary management of the injury can provide the players with a reasonable chance to return to play at the pre-injury level.
View Article and Find Full Text PDFEffect of ELHLD peptide for stifle function recovery after tibial plateau leveling osteotomy in dogs.
J Vet Sci
October 2024
Department of Veterinary Surgery, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea.
Importance: Patients with arthritis and ruptured cruciate ligaments typically require surgery. Following surgery, it is necessary to improve joint function in early stage.
Objective: This study aimed to investigate the impact of intraoperative intra-articular injection of the ELHLD peptide (L-glutamyl-L-leucyl-L-histidyl-L-leucyl-L-aspartic acid) on postoperative stifle function in patients with medial patella luxation grade 3 and osteoarthritis grade 2 undergoing tibial plateau leveling osteotomy due to anterior cruciate ligament (ACL) rupture.
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