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CRFR1 in AgRP Neurons Modulates Sympathetic Nervous System Activity to Adapt to Cold Stress and Fasting. | LitMetric

CRFR1 in AgRP Neurons Modulates Sympathetic Nervous System Activity to Adapt to Cold Stress and Fasting.

Cell Metab

Department of Neurobiology, The Ruhman Family Laboratory for Research on the Neurobiology of Stress, Weizmann Institute of Science, 76100 Rehovot, Israel; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, 80804 Munich, Germany. Electronic address:

Published: June 2016

AI Article Synopsis

  • The corticotropin-releasing factor receptor type 1 (CRFR1) is crucial for the body's stress response, particularly in managing autonomic reactions.
  • Research reveals that nearly half of the CRFR1 neurons in the arcuate nucleus of the hypothalamus also express agouti-related peptide (AgRP), with some originating from precursor neurons.
  • In female mice lacking CRFR1 specifically in AgRP neurons, there is a notable failure in thermoregulation and glucose production during stress, indicating that CRFR1 is vital for proper sympathetic nervous system function under stress.

Article Abstract

Signaling by the corticotropin-releasing factor receptor type 1 (CRFR1) plays an important role in mediating the autonomic response to stressful challenges. Multiple hypothalamic nuclei regulate sympathetic outflow. Although CRFR1 is highly expressed in the arcuate nucleus (Arc) of the hypothalamus, the identity of these neurons and the role of CRFR1 here are presently unknown. Our studies show that nearly half of Arc-CRFR1 neurons coexpress agouti-related peptide (AgRP), half of which originate from POMC precursors. Arc-CRFR1 neurons are innervated by CRF neurons in the hypothalamic paraventricular nucleus, and CRF application decreases AgRP(+)CRFR1(+) neurons' excitability. Despite similar anatomy in both sexes, only female mice selectively lacking CRFR1 in AgRP neurons showed a maladaptive thermogenic response to cold and reduced hepatic glucose production during fasting. Thus, CRFR1, in a subset of AgRP neurons, plays a regulatory role that enables appropriate sympathetic nervous system activation and consequently protects the organism from hypothermia and hypoglycemia.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911344PMC
http://dx.doi.org/10.1016/j.cmet.2016.04.017DOI Listing

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