Investigation of apoptotic events at molecular level induced by SERS guided targeted theranostic nanoprobe.

Nanoscale

CSIR-National Institute for Interdisciplinary Science & Technology (NIIST), Chemical Science & Technology Division (CSTD), Organic chemistry section, Industrial Estate, Thiruvananthapuram 695019, Kerala, India. and Academy of Scientific and Innovative Research (AcSIR) - CSIR-NIIST, Thiruvananthapuram, India.

Published: June 2016

Herein, we have examined distinctive structural and functional variations of cellular components during apoptotic cell death induced by a targeted theranostic nanoprobe, MMP-SQ@GNR@LAH-DOX, which acted as a SERS "on/off" probe in the presence of a MMP protease and executed synergistic photothermal chemotherapy, as reflected by the SERS fingerprinting, corresponding to the phosphodiester backbone of DNA.

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Source
http://dx.doi.org/10.1039/c6nr03385gDOI Listing

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