AI Article Synopsis
- The study analyzed the importance of serum free light chain ratio (sFLCR) in diagnosing and predicting outcomes for newly diagnosed multiple myeloma (NDMM) patients based on data from 82 patients.
- The results showed a high rate of abnormalities in sFLC and sFLCR, with overall survival significantly better for patients with high sFLCR compared to those with low sFLCR.
- Key findings indicated that the high sFLCR group had worse health indicators, including higher levels of serum creatinine and more advanced disease stages, and response to chemotherapy was lower in the high sFLCR group.
Article Abstract
Objective: The roles of serum free light chain ratio (sFLCR) in the diagnosis and prognosis of newly diagnosed multiple myeloma (NDMM) patients were analyzed.
Methods: The clinical data was retrospectively analyzed for 82 newly diagnosed multiple myeloma (NDMM) patients in the first affiliated hospital of Soochow University from September 28, 2012 to July 18, 2105. The serum free light chain levels were measured and κ/λ ratios were calculated, so we could analyze the roles of sFLCR in the diagnosis and prognosis of newly diagnosed multiple myeloma (NDMM) patients.
Results: It was 85.5% (70/82) positive of M protein by serum protein electrophoresis (SFE) and 93.9%(77/82) by serum immunofixation electrophoresis (IFE). Both sFLC and sFLCR abnormalities were 96.3% (79/82). The estimated 40-months overall survival was 87% for the high free light chain ratio group (sFLCR ≥100 or≤0.01) and 61% for the low free light chain ratio group (0.01
Conclusion: sFLC assay is much more sensitive than the common methods used, such as SPE and IFE for the diagnosis of MM. The patients with significantly abnormal sFLCR have more tumor burden, higher aggressive progression, and adverse prognosis. Compared with the patients who have normal renal function, the patients with renal insufficiency acquire the same effect after receiving reasonable treatment actively.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348314 | PMC |
| http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2016.05.005 | DOI Listing |
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