AI Article Synopsis
Article Abstract
A chymotrypsin-like protease was detected along with elastase 1 in pancreatic secretion and stool. This enzyme was isolated from necrobiotic human pancreas, purified, partially characterized and designated as chymotrypsin B. Quantitative studies by rocket immunoelectrophoresis indicated that neither elastase 1 nor chymotrypsin B was degraded during intestinal passage. On the basis of a clinical study, both enzymes were found to reflect pancreatic function.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0009-9120(89)80003-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
KF4 Anti-Chymotrypsin-like Elastase 1 Antibody and Purified Alpha-1 Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine Alpha-1 Antitrypsin Deficiency.
Chronic Obstr Pulm Dis
November 2024
Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, United States.
Alpha-1 antitrypsin (AAT) deficiency is the most common genetic cause of emphysema. Chymotrypsin-like Elastase 1 (CELA1) is a serine protease neutralized by AAT and is important in emphysema progression. Cela1-deficiency is protective in a murine models of AAT-deficient emphysema.
View Article and Find Full Text PDFAeruginosin 525 (AER525) from Cyanobacterium Sp. (KUCC C2): A New Serine Proteases Inhibitor.
Mar Drugs
November 2024
Department of Marine Biology and Biotechnology, University of Gdańsk, M. J. Piłsudskiego 46, PL-81378 Gdynia, Poland.
Aeruginosins (AERs) are one of the most common classes of cyanobacterial peptides synthesised through a hybrid non-ribosomal peptide synthase/polyketide synthase pathway. They have been found in , , /, and The presence of AER in isolated from the Curonian Lagoon was reported for the first time in our previous work. Here, the structure of aeruginosin 525 (AER525), isolated from sp.
View Article and Find Full Text PDFOccurrence of protease inhibitors in freshwater cyanobacterium Woronichinia naegeliana (Unger) Elenkin.
J Phycol
November 2024
Kraków Water, Krakow, Poland.
Article Synopsis
- Cyanobacteria produce various secondary metabolites, including bioactive oligopeptides with unclear functions, particularly from the under-studied species Woronichinia naegeliana.
- * The oligopeptides cyanopeptolin 1081 and anabaenopeptin 899 are known to negatively impact zooplankton and show structural similarities to related compounds.
- * Enzyme assays demonstrate that cyanopeptolin 1081 specifically inhibits chymotrypsin and elastase, while anabaenopeptin 899 selectively inhibits carboxypeptidase A, indicating their potential as strong enzyme inhibitors in aquatic environments.*
The High-Affinity Chymotrypsin Inhibitor Eglin C Poorly Inhibits Human Chymotrypsin-Like Protease: Gln192 and Lys218 Are Key Determinants.
Proteins
February 2025
Department of Biochemistry, ELTE Eötvös Loránd University, Budapest, Hungary.
Eglin C, a small protein from the medicinal leech, has been long considered a general high-affinity inhibitor of chymotrypsins and elastases. Here, we demonstrate that eglin C inhibits human chymotrypsin-like protease (CTRL) weaker by several orders of magnitude than other chymotrypsins. In order to identify the underlying structural aspects of this unique deviation, we performed comparative molecular dynamics simulations on experimental and AlphaFold model structures of bovine CTRA and human CTRL.
View Article and Find Full Text PDFSynthesis and Optimization of Small Molecule Inhibitors of Prostate Specific Antigen.
ACS Med Chem Lett
September 2024
Obstetrics, Gynecology and Women's Health, School of Medicine, University of Missouri - Columbia, Columbia, Missouri 65211, United States.
Semen liquefaction is a postejaculation process that transforms semen from a gel-like (coagulated) form to a water-like consistency (liquefied). This process is primarily regulated by serine proteases from the prostate gland, most prominently, prostate-specific antigen (PSA; KLK3). Inhibiting PSA activity has the potential to impede liquefaction of human semen, presenting a promising target for nonhormonal contraception in the female reproductive tract.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!