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Adipokines and Cardiometabolic Heart Failure with Preserved Ejection Fraction: A State-of-the-Art Review.
Diagnostics (Basel)
November 2024
Department of Cardiology & Heart Failure Outpatient Clinic, Sismanogleio-Amalia Fleming General Hospital, 14 25is Martiou Str., 15127 Melissia, Greece.
Background: Cardiometabolic heart failure with preserved ejection fraction (HFpEF) is largely driven by obesity-related factors, including adipokines and bioactive peptides primarily secreted by the adipose tissue, such as leptin, adiponectin, and resistin. These molecules link metabolic dysregulation to cardiovascular dysfunction, influencing HFpEF progression and patient outcomes Methods: A comprehensive literature search was conducted in PubMed up to 20 November 2024, using keywords and MeSH terms, such as "HFpEF", "adipokines", "leptin", "adiponectin", and "resistin", yielding 723 results. Boolean operators refined the search, and reference lists of key studies were reviewed.
View Article and Find Full Text PDFSystematic review and meta-analyses of adipokine levels in hypothyroidism: a role for retinol-binding protein 4.
Expert Rev Endocrinol Metab
December 2024
Centro de Investigaciones Endocrinológicas "Dr. César Bergadá" Consejo Nacional de Investigaciones Científicas y Técnicas - Fundación de Endocrinología Infantil - División de Endocrinología - Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina.
Background: Hypothyroidism (HT) is associated with numerous well-characterized comorbidities and established biomarkers for subclinical atherosclerosis which may lead to an elevated risk of cardiovascular disease; however, the precise molecular mechanism underlying these pathological features remains elusive. Increased levels of adipokines may have adverse effects on multiple atherosclerotic risk factors in HT. Different studies have evaluated the association between HT and adipokines with conflicting results.
View Article and Find Full Text PDFThe role of adipokines in the pathogenesis of psoriasis - a focus on resistin, omentin-1 and vaspin.
Expert Opin Ther Targets
July 2024
Department of Physiology, Pomeranian Medical University, Szczecin, Poland.
Background: Psoriasis is a chronic immune-mediated skin condition with several types of manifestation, including psoriatic arthritis. In recent years, studies have demonstrated multiple molecules and mechanisms that play important roles in the pathophysiology of psoriasis. Studies have been conducted to determine the role of adipokines, bioactive peptides secreted by the adipose tissue, in the pathogenesis of inflammatory diseases.
View Article and Find Full Text PDFOsteoarthritis, adipokines and the translational research potential in small animal patients.
Front Vet Sci
May 2024
Department for Small Animals, Soft Tissue and Orthopaedic Surgery Service, College of Veterinary Medicine, University of Leipzig, Leipzig, Germany.
Osteoartritis (OA) is a debilitating disease affecting both humans and animals. In the early stages, OA is characterized by damage to the extracellular matrix (ECM) and apoptosis and depletion of chondrocytes. OA progression is characterized by hyaline cartilage loss, chondrophyte and osteophyte formation, thickening of the joint capsule and function loss in the later stages.
View Article and Find Full Text PDFThe role of adipokines in osteoporosis management: a mini review.
Front Endocrinol (Lausanne)
March 2024
The Royal College of Surgeons in Ireland - Medical University of Bahrain, Al Sayh, Bahrain.
The prevalence of osteoporosis has been on the rise globally. With ageing populations, research has sought therapeutic solutions in novel areas. One such area is that of the adipokines.
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