AI Article Synopsis
- As antibiotic resistance grows and new antibiotics are harder to develop, urgent measures are needed to combat serious bacterial and fungal infections.
- Healthcare-associated infections (HAIs) are significant contributors to illness, death, and healthcare costs, driven largely by antibiotic usage.
- There are promising vaccine candidates in advanced clinical stages for pathogens like C. difficile, S. aureus, and P. aeruginosa, along with other immune interventions like monoclonal antibodies being developed to prevent these infections.
Article Abstract
As antibiotic resistance increases and the rate of antibiotic development slows, it is becoming more urgent to develop novel approaches to prevent and mitigate serious bacterial and fungal infections. Healthcare-associated infections (HAIs), including those caused by Clostridium difficile, Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter baumannii, carbapenem-resistant Enterobacteriaceae, and Candida species, are a major cause of morbidity, mortality, and healthcare costs. HAIs are also a key driver of antibiotic use. Vaccines directed toward these pathogens could help prevent a large number of HAIs and associated antibiotic use if administered to targeted populations. Despite numerous scientific and operational challenges, there are vaccine candidates in late-stage clinical development for C. difficile, S. aureus, and P. aeruginosa Basic, preclinical, and early clinical research to develop vaccines for other types of HAIs is also under way. In addition, other prophylactic immune interventions, such as monoclonal antibodies, for several of these pathogens are in advanced development. Here we describe the promise, challenges, and current pipeline of vaccines to prevent HAIs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006206 | PMC |
| http://dx.doi.org/10.1093/cid/ciw333 | DOI Listing |
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