AI Article Synopsis
- The study investigates how genetic variations affect the impact of prenatal exposure to perfluorinated compounds (PFCs) on birth weight.
- Results show that specific PFCs in cord blood are linked to lower birth weights, particularly in mothers with a certain genetic variant (GSTM1 null).
- The research highlights the role of genetic susceptibility in the relationship between prenatal PFC exposure and birth outcomes.
Article Abstract
Objective: The aim of this study was to investigate the effect of genetic polymorphisms on the association of prenatal exposure to perfluorinated compounds (PFCs) with birth weight.
Methods: We analyzed the level of eight PFCs in cord blood and two genetic polymorphisms in maternal blood of 268 subjects.
Results: Concentrations of perfluorooctanoic acid, perfluorooctane sulfonate, perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluoroundecanoic acid (PFUnDA) showed significant association with a decrease in birth weight (P < 0.05). In mothers with glutathione S-transferase M1 (GSTM1) null genotype, concentrations of PFNA, PFDA, and PFUnDA showed significantly negative association with birth weight (P < 0.05).
Conclusion: Our findings indicated that GSTM1 polymorphism might affect the association between exposure to PFCs and birth weight, suggesting the effect of genetic susceptibility on the relationship between prenatal PFCs exposure and birth outcomes.
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| http://dx.doi.org/10.1097/JOM.0000000000000739 | DOI Listing |
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