Suppression of a nuclear pore protein Nup358/RanBP2 is linked to mitotic cell death, but the clinical relevance of this link is unknown. In a recent issue of Cell, Vecchione et al. (2016) show that in approximately 10% of BRAF-like colorectal cancer (CC) patients, Nup358/RanBP2 is critical for survival. Treatment with vinorelbine, a microtubule-depolymerizing drug that inhibits mitosis, might be a potential treatment for these CCs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421494 | PMC |
| http://dx.doi.org/10.1016/j.chembiol.2016.05.004 | DOI Listing |
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