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Photoimmunologic Therapy of Stubborn Biofilm via Inhibiting Bacteria Revival and Preventing Reinfection.
Adv Mater
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School of Biomedical Engineering, Sichuan University, Chengdu, 610065, China.
Stubborn biofilm infections pose serious threats to public health. Clinical practices highly rely on mechanical debridement and antibiotics, which often fail and lead to persistent and recurrent infections. The main culprits are 1) persistent bacteria reviving, colonizing, and rejuvenating biofilms, and 2) secondary pathogen exposure, particularly in individuals with chronic diseases.
View Article and Find Full Text PDFNanoarchitectonics of Antibiotic-Releasing Acicular Nanozymes for Targeting and Inducing Cuproptosis-like Death to Eliminate Drug-Resistant Bacteria.
ACS Nano
September 2024
Department of Burns, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, P. R. China.
A series of progress has been made in the field of antimicrobial use of nanozymes due to their superior stability and decreased susceptibility to drug resistance. However, catalytically generated reactive oxygen species (ROS) are insufficient for coping with multidrug-resistant organisms (MDROs) in complex wound environments due to their low targeting ability and insufficient catalytic activity. To address this problem, chemically stable copper-gallic acid-vancomycin (CuGA-VAN) nanoneedles were successfully constructed by a simple approach for targeting bacteria; these nanoneedles exhibit OXD-like and GSH-px-like dual enzyme activities to produce ROS and induce bacterial cuproptosis-like death, thereby eliminating MDRO infections.
View Article and Find Full Text PDFRecent advances in engineered polymeric materials for efficient photodynamic inactivation of bacterial pathogens.
Bioact Mater
March 2023
Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energies, School of Materials and Energy, Southwest University, Chongqing, 400715, PR China.
Nowadays, infectious diseases persist as a global crisis by causing significant destruction to public health and the economic stability of countries worldwide. Especially bacterial infections remain a most severe concern due to the prevalence and emergence of multi-drug resistance (MDR) and limitations with existing therapeutic options. Antibacterial photodynamic therapy (APDT) is a potential therapeutic modality that involves the systematic administration of photosensitizers (PSs), light, and molecular oxygen (O) for coping with bacterial infections.
View Article and Find Full Text PDFMethicillin-Resistant (MRSA): Prevalence, Antimicrobial Susceptibility Pattern, and Detection of A Gene among Cardiac Patients from a Tertiary Care Heart Center in Kathmandu, Nepal.
Infect Dis (Auckl)
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Central Department of Microbiology, Tribhuvan University, Kirtipur, Kathmandu, Nepal.
Background: Methicillin Resistant (MRSA) is a significant human pathogen associated with nosocomial infections. A in the is a marker of MRSA. The main objective of this study was to detect A and genes conferring resistance in among cardiac patients attending Sahid Gangalal National Heart Centre (SGNHC), Kathmandu, Nepal between May and November 2019.
View Article and Find Full Text PDFProfiling of gene expression in methicillin-resistant Staphylococcus aureus in response to cyclo-(L-Val-L-Pro) and chloramphenicol isolated from Streptomyces sp., SUK 25 reveals gene downregulation in multiple biological targets.
Arch Microbiol
October 2020
Faculty of Agro-Based Industry, Universiti Malaysia Kelantan, 17600, Jeli, Kelantan, Malaysia.
Article Synopsis
- Chloramphenicol (CAP) and cyclo-(L-Val-L-Pro) were isolated from a specific strain of Streptomyces and showed strong effects against methicillin-resistant Staphylococcus aureus (MRSA).
- The study used DNA microarray to analyze gene expression changes in MRSA after treatment, revealing that CAP mainly upregulated protein synthesis genes as a response to its inhibition effects.
- In contrast, cyclo-(L-Val-L-Pro) downregulated various genes related to ribosomal proteins and other pathways, indicating it targets multiple biological functions in MRSA, which could help combat antibiotic resistance more effectively than CAP.
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