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miR-199a-3p mitigates simulated microgravity-induced cardiac remodeling by targeting MEF2C.
FASEB J
January 2025
National Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing, China.
Microgravity-induced cardiac remodeling and dysfunction present significant challenges to long-term spaceflight, highlighting the urgent need to elucidate the underlying molecular mechanisms and develop precise countermeasures. Previous studies have outlined the important role of miRNAs in cardiovascular disease progression, with miR-199a-3p playing a crucial role in myocardial injury repair and the maintenance of cardiac function. However, the specific role and expression pattern of miR-199a-3p in microgravity-induced cardiac remodeling remain unclear.
View Article and Find Full Text PDFFormulation Factors Affecting the Formation of Visible-Bubbles During the Reconstitution Process of Freeze-Dried Etanercept Formulations: Protein Concentration, Stabilizers, and Surfactants.
AAPS J
January 2025
Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Freeze drying is one of the common methods to extend the long-term stability of biologicals. Biological products in solid form have the advantages of convenient transportation and stable long-term storage. However, long reconstitution time and extensive visible bubbles are frequently generated during the reconstitution process for many freeze-dried protein formulations, which can potentially affect the management efficiency of staff, patient compliance, and product quality.
View Article and Find Full Text PDFThe impact of induced stress on reactive and proactive control in depression.
PeerJ
January 2025
Department of Psychology, Aichi University of Education, Kariya, Aichi, Japan.
Background: Depression, a widespread mental health issue, is often marked by impaired cognitive control, particularly in managing proactive and reactive processes. The Dual Mechanisms of Control (DMC) framework differentiates between these two modes of cognitive control: proactive control involves sustained goal maintenance, while reactive control is more stimulus-driven and transient. Stress, known to exacerbate cognitive dysfunction in depression, may influence the balance between these control processes, though the specific effects remain poorly understood.
View Article and Find Full Text PDFLong-Term Survival of Dental Implants in a Patient With Periodontitis and Diabetes Mellitus: An Eight-Year Follow-Up Case Report.
Cureus
December 2024
Department of Periodontology & Implantology, Subharti Dental College and Hospital, Swami Vivekanand Subharti University, Meerut, IND.
Dental implants are now a standard solution for replacing missing teeth, even in patients with a history of chronic periodontitis. India is often referred to as the "diabetic capital of the world," a title that reflects the country's alarming rates of diabetes prevalence. However, the risk of complications, such as peri-implantitis and implant failure, remains a concern for these patients.
View Article and Find Full Text PDFVariations in Octreotide Dosing in Published Reports of Sulfonylurea Toxicity: A Systematic Review, 1988-Present.
J Med Toxicol
January 2025
Office of Medical Toxicology, University of Alabama Birmingham, Birmingham, USA.
Background: Octreotide is commonly used to treat hypoglycemia due to sulfonylurea toxicity, but optimal dosing for this indication is not well defined.
Methods: We performed a systematic review to identify cases in the medical literature of octreotide use for sulfonylurea poisoning. Literature published on octreotide and sulfonylureas between octreotide's FDA approval on 10/21/1988 and 8/15/2024 was reviewed.
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