AI Article Synopsis
- Neuroinflammation is linked to glial cell activation and is a significant factor in both normal aging and brain damage.
- N-acylethanolamides (NAEs) are naturally occurring compounds that have been shown to increase in the aging brain and after brain injuries, suggesting they play a role in neuroprotection.
- This review explores how NAEs can potentially mitigate neuroinflammation through actions on glial cells, focusing on their endogenous and exogenous properties and effects via PPARα activation.
Article Abstract
Neuroinflammation involves the activation of glial cells and represents a key element in normal aging and pathophysiology of brain damage. N-acylethanolamides (NAEs), naturally occurring amides, are known for their pro-homeostatic effects. An increase in NAEs has been reported in vivo and in vitro in the aging brain and in brain injury. Treatment with NAEs may promote neuroprotection and exert anti-inflammatory actions via PPARα activation and/or by counteracting gliosis. This review aims to provide an overview of endogenous and exogenous properties of NAEs in neuroinflammation and to discuss their interaction with glial cells.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844606 | PMC |
| http://dx.doi.org/10.3389/fnagi.2016.00081 | DOI Listing |
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