Sinularia polydactyla (Ehrenberg, 1834) is re-described and a lectotype assigned. This led to examination of related material from various Indo-Pacific regions. Consequently, Sinularia levi sp. n. is described from Eilat, Israel (Gulf of Aqaba, northern Red Sea) and Sinularia compressa Tixier-Durivault, 1945 and Sinularia candidula Verseveldt and Benayahu, 1983 are synonymized with Sinularia polydactyla. Additional specimens identified in the literature as Sinularia polydactyla are provisionally reassigned to other taxa.
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http://dx.doi.org/10.3897/zookeys.581.7455 | DOI Listing |
Mar Drugs
December 2020
Section of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.
Six new (, , , , and ) and twenty previously isolated (-, , -, -, and -) steroids featuring thirteen different carbocycle motifs were isolated from the organic extract of the soft coral collected from the Hurghada reef in the Red Sea. The structures and the relative configurations of the isolated natural products have been determined based on extensive analysis of their NMR and MS data. The cytotoxic, anti-inflammatory, anti-angiogenic, and neuroprotective activity of compounds -, -, -, and -, as well as their effect on androgen receptor-regulated transcription was evaluated in vitro in human tumor and non-cancerous cells.
View Article and Find Full Text PDFChin J Nat Med
November 2020
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; Open Studio for Druggability Research of Marine Natural Products, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:
Lobane-type diterpenoids are not frequently discovered from marine soft corals. In this paper, three new lobane type diterpenes, 13-methoxyloba-8,10,15(16),17(18)-tetraene (1), 8,10,13(15)Z,16E-lobatetraene (2) and 19-hydroxy-lobatetraene (3), and a new natural compound, 17,18-epoxyloba-16-acetoxy-8,10,13(15)-trien (4), co-occurring with a known related diterpenoid, 18-methoxyloba-8,10,13(15),16(17)-tetraene (5), were isolated from the South China Sea soft coral Sinularia polydactyla. The structures of new compounds were determined by extensive spectroscopic analysis and by comparison with those reported in the literature.
View Article and Find Full Text PDFBioorg Chem
January 2020
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555, Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China. Electronic address:
One new polycyclic furanobutenolide-derived norcembranoid, xiguscabrolide H (1), together with eleven known related norditerpenoids 2-12 were isolated from South China Sea soft corals Sinularia scabra and S. polydactyla, respectively. Among them, compounds 1, 6, 8, and 12 were discovered from the former species, while compounds 2-5, 7, and 9-11 were obtained from the latter species.
View Article and Find Full Text PDFSci Rep
May 2019
University of New Hampshire, Department of Molecular, Cellular, and Biomedical Sciences, Durham, NH, 03824, USA.
Like scleractinian corals, soft corals contain photosymbionts (Family Symbiodiniaceae) that provide energy for the host. Recent thermal events have resulted in soft coral bleaching in four of five years on Guam, where they dominated back-reef communities. Soft coral bleaching was examined in Sinularia maxima, S.
View Article and Find Full Text PDFMar Drugs
March 2018
State Key Laboratory of Drug Research, Shanghai Institute of MateriaMedica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China.
A new prenyleudesmane type diterpene, sinupol (), and a new capnosane type diterpenoid, sinulacetate (), were isolated from the Xisha soft coral along with five known related diterpenes (- and ). Their structures, including absolute configurations, were determined by extensive spectroscopic analysis, the comparison of their NMR data with those of related compounds, and time-dependent density functional theory electronic circular dichroism (TDDFT ECD) calculations. Both new compounds ( and ) exhibited promising inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), a potential drug target for the treatment of type II diabetes and obesity.
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